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'It's a death sentence': Local Toronto grocery store told it can no longer serve coffee
A cup of coffee is keeping a small business in Toronto alive – but it could also be a death sentence.
Indian health authorities said on Wednesday they had halted all production of New Delhi-based Maiden Pharmaceuticals after a WHO report that its cough and cold syrups exported to Gambia may be linked to the deaths of dozens of children there.
Known as a "pharmacy of the world," India supplies 45% of all generic medicines to Africa.
The deaths of 69 children in Gambia - one of the worst such incidents involving drugs from India - have come as a blow to the industry whose exports more than doubled in the last decade to hit US$24.5 billion last fiscal year.
Indian authorities inspected Maiden's main factory in the state of Haryana four times this month and said they suspended all its manufacturing activities on Tuesday after finding that the firm had been manufacturing and testing drugs in violation of rules "across its manufacturing and testing activities."
"In view of the seriousness of the contraventions observed during the investigation and its potential risk to the quality, safety and efficacy of the drug being produced, all the manufacturing activities of the firm is being stopped with immediate effect," said an order by federal and Haryana state drug regulators.
Maiden executive Naresh Kumar Goyal declined to comment.
The drugs exported to Gambia were made by Maiden in a single batch in December last year at its main factory in Haryana's Sonipat district, about 40 kms (25 miles) north of New Delhi, with a use-by-date of November, 2024, the order said.
A top Indian health official, who declined to be named, said the government would not tolerate wrongdoing but that it was important to find out what exactly happened in Gambia. He denied allegations by some critics that health regulations in India, especially at the level of states, were lax.
The government has formed a committee of four experts that will advise further action after "examining and analyzing adverse event reports, causal relationship and all related details shared by the WHO (World Health Organization)."
Indian laws allow for imprisonment and fines for selling spurious drugs.
But the source said the WHO had yet to share any report establishing a direct link to the deaths with the Indian-made medicines.
WHO Assistant Director-General Mariângela Simão told a virtual news conference it was working closely with Indian authorities to investigate Maiden's cough and cold syrups.
She said the WHO's conclusion about the deaths being linked to Maiden's medicines was based on analysis of several samples of medicines that were used by hospitalized children.
Maiden says on its website it has an annual production capacity of 2.2 million syrup bottles, 600 million capsules, 18 million injections, 300,000 ointment tubes and 1.2 billion tablets at its Haryana factories. It says it has two other factories in the state apart from the main one.
The WHO issued a medical product alert last week asking regulators to remove Maiden goods from the market.
The UN health agency said that laboratory analysis of four Maiden products - Promethazine Oral Solution, Kofexmalin Baby Cough Syrup, Makoff Baby Cough Syrup and Magrip N Cold Syrup - had "unacceptable" amounts of diethylene glycol and ethylene glycol, which can be toxic and lead to acute kidney injury.
Diethylene glycol and ethylene glycol are used as a cheaper alternative in some pharmaceutical products to glycerine, a solvent or thickening agent in many cough syrups.
Gambian police, in a preliminary investigation report on Tuesday, said that the deaths of 69 children from acute kidney injury was linked to the cough syrups made in India and imported via Atlanta-based Atlantic Pharmaceuticals.
Atlantic could not be reached for comment.
The cough syrups had been approved for export only to Gambia, India says, although the WHO says they may have gone elsewhere through informal markets.
Indonesia said on Wednesday it would investigate cases of acute kidney injury which has caused the deaths of more than 20 children in its capital Jakarta this year, but that there was no connection with the cases in Gambia.
Reporting by Tanvi Mehta and Krishna Das; Additional reporting by Manas Mishra; Editing by Raju Gopalakrishnan, Kirsten Donovan, Alex Richardson and Emelia Sithole-Matarise
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