DEVELOPING 'Numerous' officers shot in 'active situation' in Charlotte, North Carolina, police say
'Numerous law enforcement officers' have been shot in an 'active situation' in Charlotte, North Carolina, police say.
Some U.S. adults are a step closer to getting updated COVID-19 boosters this fall, as government advisers voted Tuesday that it's time to tweak shots to better match the most recent virus variants.
The Food and Drug Administration will have to decide the exact recipe but expect a combination shot that adds protection against a version of the super-contagious omicron variant to the original vaccine.
Advisers to the FDA voted 19-2 that some version of omicron should be part a fall booster campaign, an effort to blunt an expected COVID-19 surge.
“We are going to be behind the eight-ball if we wait longer,” agreed Dr. Mark Sawyer of the University of California, San Diego.
But panelists cautioned that the recommendation doesn't necessarily mean everyone would get a tweaked booster - they might be urged only for older adults or those at high risk from the virus.
Current COVID-19 vaccines have saved millions of lives globally and those used in the U.S. still offer strong protection against hospitalization and death -- especially after a booster dose. But their ability to block infection dropped markedly when the super-contagious omicron mutant emerged.
Pfizer and Moderna tested shots updated to better match the omicron that surged over the winter, but that first mutant has disappeared -- replaced by its genetically distinct relatives. The two newest omicron cousins, called BA.4 and BA.5, together now make up half of U.S. cases, according to the Centers for Disease Control and Prevention.
Only about half of vaccinated Americans have gotten a single booster. And while a second booster that's recommended for people 50 and older again restores protection, only a quarter of those eligible have gotten one. Authorities hope an updated booster for fall might entice more interest.
So what's the evidence for a recipe change? Among the evidence Tuesday:
-- Both Moderna and Pfizer found what scientists call “bivalent” shots -- a combination of the original vaccine plus omicron protection -- substantially boosted levels of antibodies capable of fighting that variant, more than simply giving another regular dose. Many scientists favor the combination approach because it preserves the original vaccines' proven benefits, which include some cross-protection against other mutants that have cropped up during the pandemic.
Both companies found the tweaked shots also boosted antibodies against BA.4 and BA.5 but not by nearly as many.
-- Pfizer and its partner BioNTech also are offering up an omicron-only shot. Also in animal testing is vaccine further tweaked to match BA.4 and BA.5.
-- A third company, Novavax, is awaiting FDA authorization of a more traditional kind of COVID-19 vaccine, protein-based shots. It argued that a booster of its regular vaccine promises a good immune response against the new omicron mutants.
Another issue: Advisers to the World Health Organization recently said that omicron-tweaked shots may be beneficial as a booster rather than a replacement for first vaccinations - because they should increase the breadth of people's protection against multiple variants.
“We don't want the world to lose confidence in vaccines that are currently available,” said Dr. Kanta Subbarao, a virologist who chairs that WHO committee.
The Associated Press Health and Science Department receives support from the Howard Hughes Medical Institute's Department of Science Education. The AP is solely responsible for all content.
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