Grandparents killed in wrong-way crash on Hwy. 401 identified
A 60-year-old man and a 55-year-old woman killed in a wrong-way crash on Highway 401 earlier this week have been identified by the Consulate General of India in Toronto.
A booster dose of the COVID-19 vaccine developed by Pfizer and German partner BioNTech restored efficacy to 95.6% against the virus, including the Delta variant, data released by the companies from a large study showed on Thursday.
The companies said in a press release the trial, which has not been peer-reviewed, tested 10,000 participants aged 16 and older, and found that the booster shot had a favorable safety profile.
The trial results come a day after the U.S. Food and Drug Administration authorized booster doses of the COVID-19 vaccines from Moderna and Johnson & Johnson, and said Americans could choose a different shot from their original inoculation as a booster.
The agency previously authorized boosters of the Pfizer/BioNTech shot at least six months after the first round of shots to increase protection for people aged 65 and older, those at risk of severe disease and those who are exposed to the virus through their work.
Dr. Walid Gellad, a professor at University of Pittsburgh's medical school, said there seems to be a benefit of having the third dose in the delta wave for symptomatic COVID-19.
"I'm just still very curious if this is primarily in people who are much much older. Because what we don't want to do is run out and give boosters to 25-year-olds who had COVID before and got two doses of the vaccine, just based on this press release," Gellad said.
Pfizer had said its two-shot vaccine's efficacy drops over time, citing a study that showed 84% effectiveness from a peak of 96% four months after a second dose. Some countries had already gone ahead with plans to give booster doses.
The drugmakers said on Thursday the median time between the second dose and the booster shot or the placebo in the study was around 11 months, adding there were only five cases of COVID-19 in the booster group, compared with 109 cases in the group which received the placebo shot.
The median age of the participants was 53 years, with 55.5% of participants between 16 and 55 years, and 23.3% at 65 years or older.
Jefferies analyst Michael Yee said the trial results add to mounting data that boosters could help in providing long-lasting protection from symptomatic infection.
There were no reported cases of severe disease, suggesting robust protection from infection with only the primary vaccination series, Yee wrote in a note.
The companies said they would submit detailed results of the trial for peer-reviewed publication to the U.S. FDA, the European Medicines Agency and other regulatory agencies, as soon as possible.
A 60-year-old man and a 55-year-old woman killed in a wrong-way crash on Highway 401 earlier this week have been identified by the Consulate General of India in Toronto.
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