Prince William says wife Kate is 'doing well'
Prince William said on Friday his wife Kate was 'doing well' in a rare public comment about the Princess of Wales as she undergoes preventative chemotherapy for cancer.
The inexpensive and well-known drug fluvoxamine can save the lives of COVID-19 patients and cut hospital admissions by up to 30 per cent, according to a new study.
The study, co-led by researchers at McMaster University and published Wednesday in The Lancet, treated 741 randomly selected Brazilian COVID-19 patients with fluvoxamine, and another 756 with a placebo. All of the patients were treated from Jan. 15 to Aug. 6 of 2021, and were monitored for 28 days. All of the patients were unvaccinated.
Fluvoxamine is a selective serotonin reuptake inhibitor (SSRI) antidepressant that is used to treat mental health conditions such as depression and obsessive-compulsive disorders.
Out of the participants who received fluvoxamine, 10.6 per cent (79) required treatment by a doctor for more than six hours or were hospitalized. By comparison, 15.7 per cent (119) of the participants who received placebos were hospitalized or needed physician treatment for more than six hours. When patients took all of their drugs, the noted beneficial effect went up to 65 per cent, the study found.
Dr. Edward Mills, the co-principal investigator of the trial, said the results could be a potential game-changer, particularly in developing countries with low vaccination rates.
“It’s a very large treatment effect, one that hasn’t been observed for any drug yet,” he told CTV National News in a video interview.
“It could be one of our most powerful weapons against the virus and its effectiveness is one of the most important discoveries we have made since the pandemic began,” he said in a separate written statement.
Fluvoxamine has been used since the 1990s and its safety profile is well known, says Mills. It costs about $4 per 10-day course, which is far cheaper than other treatments, he said.
“For fluvoxmine, 10 days’ worth of drugs costs $4. The monoclonal antibodies for treatment at the very same stage of disease cost $2,100,” he told CTV National News.
Mills says having an easily-accessible drug can allow hospitals to avoid expensive and sometimes risky treatments.
The drug was identified early in the pandemic for its anti-inflammatory properties, which could help reduce the severe immune responses patients may have in response to COVID-19. These severe responses, called “Cytokine storms,” can cause potentially lethal organ damage.
Although death was not a primary outcome of the study, further analysis found that of the participants who took at least 80 per cent of their doses, there was one death among the group that received fluvoxamine, compared to 12 deaths among the placebo group.
Mills said the next step is to evaluate whether or not fluvoxamine combined with other interventions, like steroids, can have a larger treatment effect. As well, although fluvoxamine is widely available, it is not on the WHO’s Essential Medicines list. However, fluoxetine, a closely-related antidepressant, is on the WHO list.
He says it’s important to look at if similar antidepressants can also be used to treat COVID-19.
“This is one particular antidepressant, are there other antidepressants within the same family that may be cheaper, have a longer half-life (the amount of time it’s in your system), or are more widely available? Would they demonstrate the same kind of treatment benefit?” he told CTV National News. “We’re going to have to examine this question.”
Prince William said on Friday his wife Kate was 'doing well' in a rare public comment about the Princess of Wales as she undergoes preventative chemotherapy for cancer.
Canadian Blood Services issued an apology on Friday to the LGBTQ2S+ community for what it now admits was a harmful and discriminatory blood donation policy that prevented sexually active men who have sex with men and some trans people from donating blood and plasma.
Toronto Mayor Olivia Chow says that she is hopeful an announcement could be made soon amid multiple reports that a WNBA team is coming to Toronto in 2026.
A 4.2-magnitude earthquake was recorded west of Vancouver Island early Friday morning.
A provincial coroner will be investigating the death of 68-year-old David Lippert, who suffered a cardiac arrest while waiting in a crowded emergency room in Kitchener, Ont.
Police in Newfoundland say patrol officers were assaulted Thursday by a "very irate male" wielding a block of cheese.
Average hourly wages among Canadian employees rose to $34.95 on a year-over-year basis in April, a 4.7 per cent increase, according to a Statistics Canada report released Friday morning.
Andy Kim's 'Rock Me Gently' is marking a major milestone, as it celebrates its 50th anniversary.
A family of fifth generation farmers from Ituna, Sask. are trying to find answers after discovering several strange objects lying on their land.
A family of fifth generation farmers from Ituna, Sask. are trying to find answers after discovering several strange objects lying on their land.
A Listowel, Ont. man, drafted by the Hamilton Tigercats last week, is also getting looks from the NFL, despite only playing 27 games of football in his life.
A small Ajax dessert shop that recently received a glowing review from celebrity food critic Keith Lee is being forced to move after a zoning complaint was made following the social media influencer’s visit last month.
The Canada Science and Technology Museum is inviting visitors to explore their poop. A new exhibition opens at the Ottawa museum on Friday called, 'Oh Crap! Rethinking human waste.'
The Regina Police Service says it is the first in Saskatchewan and possibly Canada to implement new technology in its detention facility that will offer real-time monitoring of detainees’ vital health metrics.
The stakes have been set for a bet between Vancouver and Edmonton's mayors on who will win Round 2 of the Stanley Cup playoffs.
A grieving mother is hosting a helmet drive in the hopes of protecting children on Manitoba First Nations from a similar tragedy that killed her daughter.
A chicken farmer near Mattawa made an 'eggstraordinary' find Friday morning when she discovered one of her hens laid an egg close to three times the size of an average large chicken egg.
A P.E.I. lighthouse and a New Brunswick river are being honoured in a Canada Post series.