'Most of the city is evacuating': Gridlock on Alberta highway after evacuation order in Fort McMurray
Four Fort McMurray neighbourhoods were ordered to evacuate on Tuesday as a wildfire gets closer to the city.
The National Institutes of Health is beginning a handful of studies to test possible treatments for long COVID, an anxiously awaited step in U.S. efforts against the mysterious condition that afflicts millions.
Monday's announcement from the NIH's $1.15 billion RECOVER project comes amid frustration from patients who've struggled for months or even years with sometimes-disabling health problems -- with no proven treatments and only a smattering of rigorous studies to test potential ones.
"This is a year or two late and smaller in scope than one would hope but nevertheless it's a step in the right direction," said Dr. Ziyad Al-Aly of Washington University in St. Louis, who isn't involved with NIH's project but whose own research highlighted long COVID's toll. Getting answers is critical, he added, because "there's a lot of people out there exploiting patients' vulnerability" with unproven therapies.
Scientists don't yet know what causes long COVID, the catchall term for about 200 widely varying symptoms.
"If I get 10 people, I get 10 answers of what long COVID really is," U.S. Health and Human Services Secretary Xavier Becerra said.
That's why so far the RECOVER initiative has tracked 24,000 patients in observational studies to help define the most common and burdensome symptoms --- findings that now are shaping multipronged treatment trials. The first two will look at:
Two additional studies will open in the coming months. One will test treatments for sleep problems. The other will target problems with the autonomic nervous system -- which controls unconscious functions like breathing and heartbeat -- including the disorder called POTS.
A more controversial study of exercise intolerance and fatigue also is planned, with NIH seeking input from some patient groups worried that exercise may do more harm than good for certain long COVID sufferers.
The trials are enrolling 300 to 900 adult participants for now but have the potential to grow. Unlike typical experiments that test one treatment at a time, these more flexible "platform studies" will let NIH add additional potential therapies on a rolling basis.
"We can rapidly pivot," Dr. Amy Patterson with the NIH explained. A failing treatment can be dropped without ending the entire trial and "if something promising comes on the horizon, we can plug it in."
The flexibility could be key, according to Dr. Anthony Komaroff, a Harvard researcher who isn't involved with the NIH program but has long studied a similarly mysterious disorder known as chronic fatigue syndrome or ME/CFS. For example, he said, the Paxlovid study "makes all sorts of sense," but if a 25-day dose shows only hints of working, researchers could extend the test to a longer course instead of starting from scratch.
Komaroff also said that he understands people's frustration over the wait for these treatment trials, but believes NIH appropriately waited "until some clues came in about the underlying biology," adding: "You've got to have targets."
------
The Associated Press Health and Science Department receives support from the Howard Hughes Medical Institute's Science and Educational Media Group. The AP is solely responsible for all content.
Four Fort McMurray neighbourhoods were ordered to evacuate on Tuesday as a wildfire gets closer to the city.
Saskatchewan RCMP have revealed that a historic sexual assault investigation has led to the discovery of alleged crimes against children dating back to 2005.
Less than a week after two public sculptures featuring a livestream between Dublin, Ireland, and New York City debuted, 'inappropriate behaviour' in real-time interactions between people in the two cities has prompted a temporary shutdown.
After a final frame that saw the visiting Vancouver Canucks claw their way back and tie the game late, a point shot by Oilers defenceman Evan Bouchard with 38 seconds left (until what seemed like certain overtime) iced the 3-2 victory for Edmonton to knot the series.
Kansas City Chiefs kicker Harrison Butker railed against Pride month, working women, President Biden's leadership during the COVID-19 pandemic and abortion during a commencement address at Benedictine College last weekend.
King Charles III has unveiled the first portrait of the monarch completed since he assumed the throne, a vivid image that depicts him in the bright red uniform of the Welsh Guards against a background of similar hues.
The annual list of Canada's top restaurants in the country was just released and here are the places that made the 2024 cut.
The province has released more information on its plan to break up Alberta Health Services and replace it with four sector-based health agencies.
The Biden administration has told key lawmakers it is sending a new package of more than US$1 billion in arms and ammunition to Israel, two congressional aides said Tuesday.
A team is ready to help an entangled North Atlantic right whale in the Gulf of St. Lawrence.
A $200 reward is being offered by a North Vancouver family for the safe return of their beloved chicken, Snowflake.
Two daughters and a mother were reunited online 40 years later thanks to a DNA kit and a Zoom connection despite living on three separate continents and speaking different languages.
Mother's Day can be a difficult occasion for those who have lost or are estranged from their mom.
YES Theatre Young Company opened its acclaimed kids’ show, One Small Step, at Sudbury Theatre Centre on Saturday.
An Ottawa pizzeria is being recognized as one of the top 20 deep-dish pizzas in the world.
A family of fifth generation farmers from Ituna, Sask. are trying to find answers after discovering several strange objects lying on their land.
A Listowel, Ont. man, drafted by the Hamilton Tigercats last week, is also getting looks from the NFL, despite only playing 27 games of football in his life.
The threat of zebra mussels has prompted the federal government to temporarily ban watercraft from a Manitoba lake popular with tourists.