BREAKING Ontario's 'crypto king' Aiden Pleterski arrested
Aiden Pleterski, the self-proclaimed 'crypto king' from Whitby, Ont., has been arrested in Durham Region after allegedly running a Ponzi scheme worth more than $40 million.
The inexpensive and well-known drug fluvoxamine can save the lives of COVID-19 patients and cut hospital admissions by up to 30 per cent, according to a new study.
The study, co-led by researchers at McMaster University and published Wednesday in The Lancet, treated 741 randomly selected Brazilian COVID-19 patients with fluvoxamine, and another 756 with a placebo. All of the patients were treated from Jan. 15 to Aug. 6 of 2021, and were monitored for 28 days. All of the patients were unvaccinated.
Fluvoxamine is a selective serotonin reuptake inhibitor (SSRI) antidepressant that is used to treat mental health conditions such as depression and obsessive-compulsive disorders.
Out of the participants who received fluvoxamine, 10.6 per cent (79) required treatment by a doctor for more than six hours or were hospitalized. By comparison, 15.7 per cent (119) of the participants who received placebos were hospitalized or needed physician treatment for more than six hours. When patients took all of their drugs, the noted beneficial effect went up to 65 per cent, the study found.
Dr. Edward Mills, the co-principal investigator of the trial, said the results could be a potential game-changer, particularly in developing countries with low vaccination rates.
“It’s a very large treatment effect, one that hasn’t been observed for any drug yet,” he told CTV National News in a video interview.
“It could be one of our most powerful weapons against the virus and its effectiveness is one of the most important discoveries we have made since the pandemic began,” he said in a separate written statement.
Fluvoxamine has been used since the 1990s and its safety profile is well known, says Mills. It costs about $4 per 10-day course, which is far cheaper than other treatments, he said.
“For fluvoxmine, 10 days’ worth of drugs costs $4. The monoclonal antibodies for treatment at the very same stage of disease cost $2,100,” he told CTV National News.
Mills says having an easily-accessible drug can allow hospitals to avoid expensive and sometimes risky treatments.
The drug was identified early in the pandemic for its anti-inflammatory properties, which could help reduce the severe immune responses patients may have in response to COVID-19. These severe responses, called “Cytokine storms,” can cause potentially lethal organ damage.
Although death was not a primary outcome of the study, further analysis found that of the participants who took at least 80 per cent of their doses, there was one death among the group that received fluvoxamine, compared to 12 deaths among the placebo group.
Mills said the next step is to evaluate whether or not fluvoxamine combined with other interventions, like steroids, can have a larger treatment effect. As well, although fluvoxamine is widely available, it is not on the WHO’s Essential Medicines list. However, fluoxetine, a closely-related antidepressant, is on the WHO list.
He says it’s important to look at if similar antidepressants can also be used to treat COVID-19.
“This is one particular antidepressant, are there other antidepressants within the same family that may be cheaper, have a longer half-life (the amount of time it’s in your system), or are more widely available? Would they demonstrate the same kind of treatment benefit?” he told CTV National News. “We’re going to have to examine this question.”
Aiden Pleterski, the self-proclaimed 'crypto king' from Whitby, Ont., has been arrested in Durham Region after allegedly running a Ponzi scheme worth more than $40 million.
Slovakia's populist Prime Minister Robert Fico is in life-threatening condition after being wounded in a shooting after a political event Wednesday afternoon, according to his Facebook profile.
A Quebec judge rejected McGill University's request for an injunction to remove the pro-Palestinian encampment on the university's campus in downtown Montreal.
Halifax Regional Police believe a non-resident could be responsible for the infamous drugging of numerous crew members of the 'Titanic' movie with a hallucinogenic in 1996.
The federal government says it has reached a deal with Canadian National Railway Company to acquire the historic Quebec Bridge.
Several news conferences will be held Wednesday morning to update the public on the wildfire situation in Alberta, specifically near Fort McMurray where four neighbourhoods have been evacuated.
A new COVID-19 subvariant is dominant in Canada, representing just over 30 per cent of cases in the country, but infectious disease experts say there’s no sign it’ll evolve into a summer 'scarient.'
Wildfires continue to impact air quality across Western Canada with health experts and Environment Canada warning that the smoke from the blazes poses serious risks to human health.
The husband of adult film actress Stormy Daniels said on Tuesday that there’s a 'good chance' the couple will leave the country if former U.S. president Donald Trump is acquitted in his Manhattan criminal trial.
When Adam Kirschner wrote 'Slap Shot,' he never imagined the song would be embraced by his favourite team.
A team is ready to help an entangled North Atlantic right whale in the Gulf of St. Lawrence.
A $200 reward is being offered by a North Vancouver family for the safe return of their beloved chicken, Snowflake.
Two daughters and a mother were reunited online 40 years later thanks to a DNA kit and a Zoom connection despite living on three separate continents and speaking different languages.
Mother's Day can be a difficult occasion for those who have lost or are estranged from their mom.
YES Theatre Young Company opened its acclaimed kids’ show, One Small Step, at Sudbury Theatre Centre on Saturday.
An Ottawa pizzeria is being recognized as one of the top 20 deep-dish pizzas in the world.
A family of fifth generation farmers from Ituna, Sask. are trying to find answers after discovering several strange objects lying on their land.
A Listowel, Ont. man, drafted by the Hamilton Tigercats last week, is also getting looks from the NFL, despite only playing 27 games of football in his life.