Loblaw agrees to sign grocery code of conduct after months of negotiations
Loblaw Cos. Ltd. said Thursday it's ready to sign on to the grocery code of conduct, paving the way for an agreement that's been years in the making.
The inexpensive and well-known drug fluvoxamine can save the lives of COVID-19 patients and cut hospital admissions by up to 30 per cent, according to a new study.
The study, co-led by researchers at McMaster University and published Wednesday in The Lancet, treated 741 randomly selected Brazilian COVID-19 patients with fluvoxamine, and another 756 with a placebo. All of the patients were treated from Jan. 15 to Aug. 6 of 2021, and were monitored for 28 days. All of the patients were unvaccinated.
Fluvoxamine is a selective serotonin reuptake inhibitor (SSRI) antidepressant that is used to treat mental health conditions such as depression and obsessive-compulsive disorders.
Out of the participants who received fluvoxamine, 10.6 per cent (79) required treatment by a doctor for more than six hours or were hospitalized. By comparison, 15.7 per cent (119) of the participants who received placebos were hospitalized or needed physician treatment for more than six hours. When patients took all of their drugs, the noted beneficial effect went up to 65 per cent, the study found.
Dr. Edward Mills, the co-principal investigator of the trial, said the results could be a potential game-changer, particularly in developing countries with low vaccination rates.
“It’s a very large treatment effect, one that hasn’t been observed for any drug yet,” he told CTV National News in a video interview.
“It could be one of our most powerful weapons against the virus and its effectiveness is one of the most important discoveries we have made since the pandemic began,” he said in a separate written statement.
Fluvoxamine has been used since the 1990s and its safety profile is well known, says Mills. It costs about $4 per 10-day course, which is far cheaper than other treatments, he said.
“For fluvoxmine, 10 days’ worth of drugs costs $4. The monoclonal antibodies for treatment at the very same stage of disease cost $2,100,” he told CTV National News.
Mills says having an easily-accessible drug can allow hospitals to avoid expensive and sometimes risky treatments.
The drug was identified early in the pandemic for its anti-inflammatory properties, which could help reduce the severe immune responses patients may have in response to COVID-19. These severe responses, called “Cytokine storms,” can cause potentially lethal organ damage.
Although death was not a primary outcome of the study, further analysis found that of the participants who took at least 80 per cent of their doses, there was one death among the group that received fluvoxamine, compared to 12 deaths among the placebo group.
Mills said the next step is to evaluate whether or not fluvoxamine combined with other interventions, like steroids, can have a larger treatment effect. As well, although fluvoxamine is widely available, it is not on the WHO’s Essential Medicines list. However, fluoxetine, a closely-related antidepressant, is on the WHO list.
He says it’s important to look at if similar antidepressants can also be used to treat COVID-19.
“This is one particular antidepressant, are there other antidepressants within the same family that may be cheaper, have a longer half-life (the amount of time it’s in your system), or are more widely available? Would they demonstrate the same kind of treatment benefit?” he told CTV National News. “We’re going to have to examine this question.”
Loblaw Cos. Ltd. said Thursday it's ready to sign on to the grocery code of conduct, paving the way for an agreement that's been years in the making.
Veteran TSN broadcaster Darren 'Dutch' Dutchyshen, one of Canada’s best-known sports journalists, has died. He was 57. His family says 'he passed as he was surrounded by his closest loved ones.'
A ‘lifetime of abuse’ led Dallas Ly to snap and stab his mother inside a Leslieville apartment in 2022 but he never intended to kill her, his defence lawyer said during closing arguments at his murder trial on Thursday.
A Montreal father who kidnapped his daughter who has autism and lied to police when they asked where she was should serve three years in prison, a Crown prosecutor said.
To give Canadians a break on their summer road trips, Conservative Leader Pierre Poilievre is calling on Prime Minister Justin Trudeau to suspend all gas and diesel taxes from Victoria Day to Labour Day.
A medical examiner says a Massachusetts teen who participated in a spicy tortilla chip challenge died from ingesting a substance 'with a high capsaicin concentration.'
Ontario’s so-called ‘Crypto King’ Aiden Pleterski was soliciting new investors as recently as February – a year-and-a-half after he was petitioned into bankruptcy for allegedly running a Ponzi scheme worth more than $40 million - police alleged on Thursday.
Many Canadians found a message from the Canada Revenue Agency this week as they received their first direct deposit for the Canada Carbon Rebate.
A smuggling operation used drones to fly drugs across the Niagara River from Canada into upstate New York, using a newly purchased US$630,000 house along the river as a drop point, according to a criminal complaint unsealed this week.
A Starbucks fan — whose name is Winter — is visiting Canada on a purposeful journey that began with a random idea at one of the coffee chain's stores in Texas.
Members of Piapot First Nation, students from the University of Winnipeg and various other professionals are learning new techniques that will hopefully be used for ground searches of potential unmarked grave sites in the future.
ALS patient Mathew Brown said he’s hopeful for future ALS patients after news this week of research at Western University of a potential cure for ALS.
When Adam Kirschner wrote 'Slap Shot,' he never imagined the song would be embraced by his favourite team.
A team is ready to help an entangled North Atlantic right whale in the Gulf of St. Lawrence.
A $200 reward is being offered by a North Vancouver family for the safe return of their beloved chicken, Snowflake.
Two daughters and a mother were reunited online 40 years later thanks to a DNA kit and a Zoom connection despite living on three separate continents and speaking different languages.
Mother's Day can be a difficult occasion for those who have lost or are estranged from their mom.
YES Theatre Young Company opened its acclaimed kids’ show, One Small Step, at Sudbury Theatre Centre on Saturday.