KEY BISCAYNE, Fla. - John Isner erased the only break point he faced Tuesday and outlasted Canadian Milos Raonic in a serving duel at the Miami Open, 6-7 (3), 7-6 (6), 7-6 (5).

Isner, seeded 22nd, is the only American left in the men's draw. With the win, he advanced to the Key Biscayne quarterfinals for the first time.

Isner, who has yet to lose serve in three matches, was down two mini-breaks in the second-set tiebreaker before he rallied. He hit 22 aces to 12 for Raonic, with a top speed of 143 mph.

The No. 5-seeded Raonic, from Thornhill, Ont. netted a backhand on the final shot of the match. Isner won 116 points, Raonic 115.