James Brady, the affable, witty press secretary who survived a devastating head wound in the 1981 assassination attempt on President Ronald Reagan and undertook a personal crusade for gun control, died Monday. He was 73.

Brady, who spent much of the rest of his life in a wheelchair, died at a retirement community in suburban Alexandria, Virginia, where he lived with his wife.

"We are heartbroken to share the news that our beloved Jim 'Bear' Brady has passed away after a series of health issues," Brady's family said in a statement. "His wife, Sarah; son, Scott, and daughter, Missy, are so thankful to have had the opportunity to say their farewells."

He suffered a bullet wound to his head in the assassination attempt outside the Washington Hilton Hotel on March 30, 1981. Although he returned to the White House only briefly, he was allowed to keep the title of presidential press secretary and his White House salary until Reagan left office in January 1989.

Former first lady Nancy Reagan said she was "deeply saddened to learn of Jim Brady's passing today. Thinking of him brings back so many memories -- happy and sad -- of a time in all of our lives when we learned what it means to 'play the hand we're dealt."'

"I still remember vividly that day in March 1981, when Sarah and I sat together in a tiny room near the emergency room at George Washington University Hospital, trying to comfort each other while we both were gripped with unspeakable fear," Mrs. Reagan said. "The bond we established then was unlike any other."

A federal law requiring a background check on handgun buyers bears his name, as does the White House press briefing room.

President Barack Obama described Brady as a White House legend, who turned "the events of that terrible afternoon into a remarkable legacy of service." Thanks to Brady and the law bearing his name, "an untold number of people are alive today who otherwise wouldn't be," the president said in a statement.

Josh Earnest, Obama's press secretary, said Brady "showed his patriotism and commitment to the country by being very outspoken on an issue that was important to him and that he felt very strongly about."

Of the four people struck by gunfire in the assassination attempt by John Hinckley Jr. -- later found to be insane -- Brady was the most seriously wounded. A news clip of the shooting, replayed often on television, showed Brady sprawled on the ground as Secret Service agents hustled the wounded president into his limousine. Reagan was shot in one lung while a policeman and a Secret Service agent suffered lesser wounds.

Brady never regained full health. The shooting caused brain damage, partial paralysis, short-term memory impairment, slurred speech and constant pain.

The TV replays of the shooting did take a toll on Brady, however. He told The Associated Press years later that he relived the moment each time he saw it: "I want to take every bit of (that) film ... and put them in a cement incinerator, slosh them with gasoline and throw a lighted cigarette in." With remarkable courage, he endured a series of brain operations in the years after the shooting.

On Nov. 28, 1995, while he was in an oral surgeon's office, Brady's heart stopped beating and he was taken to a hospital. His wife, Sarah, credited the oral surgeon and his staff with saving Brady's life.

Brady remained as transition spokesman after Reagan's election. But his advisers appeared hesitant to give Brady the White House spokesman's job. Mrs. Reagan was said to feel the job required someone younger and better-looking than the 40-year-old, moon-faced, balding Brady.

"I come before you today not as just another pretty face, but out of sheer talent," Brady told reporters. A week later, he got the job.

He was divorced from the former Sue Beh when, in 1973, he courted Sarah Jane Kemp, the daughter of an FBI agent who was working with him in a congressional office.

Sarah Brady became involved in gun-control efforts in 1985, and later chaired Handgun Control Inc., but Brady took a few more years to join her, and Reagan did not endorse their efforts until 10 years after he was shot. Reagan's surprise endorsement -- he was a longtime National Rifle Association member and opponent of gun control laws -- began to turn the tide in Congress.

"They're not going to accuse him of being some bed-wetting liberal, no way can they do that," said Brady, who had become an active lobbyist for the bill.

The Brady Law

The Brady law -- formally known as the Brady Handgun Violence Prevention Act -- required a five-day wait and background check before a handgun could be sold. In November 1993, as President Bill Clinton signed the bill into law, Brady said: "Every once in a while you need to wake up and smell the propane. I needed to be hit in the head before I started hitting the bricks."

Clinton said Monday that Brady "transformed his own personal tragedy into an opportunity to inspire change -- for more than three decades he and Sarah encouraged all of us to create a more just and secure nation, free from handgun violence."

Gun control efforts ran aground in the current Congress, however. Despite the December 2012 slayings at an elementary school in Newtown, Connecticut, when 20 children and six adults were killed, a drive to expand background checks and a ban on assault-like weapons died in the Senate -- due in part to opposition by the National Rifle Association.

Clinton awarded Brady the Presidential Medal of Freedom in 1996. In 2000, the press briefing room at the White House was renamed in Brady's honour. The following year, Handgun Control Inc., was renamed the Brady Campaign to Prevent Gun Violence as a tribute to Brady and his wife.