WASHINGTON - The U.S. Senate voted Wednesday to triple spending for a much-acclaimed program that has treated and protected millions in Africa and elsewhere from the scourges of AIDS, malaria and tuberculosis.

The 80-16 vote committed the United States to spending up to $48 billion over the next five years for the most ambitious foreign public health program ever launched by the United States.

The legislation would replace and expand the current $15 billion act that President Bush championed in a State of the Union address and Congress passed in 2003. That act expires at the end of September.

In a statement, Bush said that when the program was launched in 2003, about 50,000 people in sub-Saharan Africa were receiving anti-retroviral treatment for HIV/AIDS. Today, the program supports lifesaving anti-retroviral treatment for more than 1.7 million people around the world, he said. It also has supported treatment and prevention programs that have helped HIV-positive women give birth to nearly 200,000 infants who are HIV-free.

"Travelling in Africa earlier this year, Laura and I had our most recent opportunity to witness the effectiveness of this program," he said. "We were honoured to see the doctors, nurses and caregivers of all faiths working to save the lives of their fellow citizens. And we met the patients, including many children, who understand and appreciate America's generosity."

The Democratic-led Senate, rarely in agreement with the White House, gave Bush credit for initiating the program. Senator Joseph Biden, (D-Del.), chairman of the Senate Foreign Relations Committee and a chief negotiator in crafting the bill, said the President's Emergency Plan for AIDS Relief, known as PEPFAR, is "the single most significant thing the president has done."

The global AIDS program will save tens of thousands, if not hundreds of thousands, of lives, Biden said, "and the president deserves our recognition for that."

Senator Richard Lugar, (R-Ind.), top Republican on the Foreign Relations Committee, and co-negotiator with Biden, said the program "has helped to prevent instability and societal collapse in a number of at-risk countries." He added that it has "facilitated deep partnerships with a new generation of African leaders, and it has improved attitudes toward the United States in Africa and other regions."

Biden said he had been co-ordinating with House leaders and was confident they could come up with a final version "within a matter of days."

The bill passed by the House in April approved $50 billion, including $5 billion for malaria, $4 billion for tuberculosis and $41 billion for AIDS. Of the AIDS money, a proportion - $2 billion next year -- would go to the international Global Fund to Fight AIDS, Tuberculosis and Malaria. Actual spending levels still have to be approved in annual appropriations bills.

The Senate was able to reject several proposed amendments offered by Republicans to cut the spending level in the bill. Supporters of tripling current spending said that 33 million are infected by HIV/AIDS around the world and that 13,000 people die every day from AIDS, TB and malaria.

"The amount per year, about $10 billion, is less than 1 per cent of this year's federal budget, and this is a small price to pay for a program that will save millions of lives and foster good will around the world," said Dr. Paul Zeitz, executive director of the Global AIDS Alliance.