A fatal multi-vehicle collision south of London closed the eastbound lanes on Highway 401 for 11 hours Tuesday. There were two collisions on the eastbound side of the highway. The first collision was at about 2:15 p.m. near Colonel Talbot Road and involved approximately three vehicles. Just after 4 p.m. OPP responded to a second collision involving a transport truck and passenger vehicle, further down the highway near Union Road. The transport truck collided with the rear of a passenger vehicle, that according to OPP was stopped in traffic. The vehicle burst into flames. Highway 401 was closed between Colonel Talbot Road and Iona Road. OPP is investigating the number of deceased individuals.