Widow looking for answers after Quebec man dies in Texas Ironman competition
The widow of a Quebec man who died competing in an Ironman competition is looking for answers.
Pharmaceutical company BioNTech said Monday that it wants to use the mRNA technology behind its coronavirus vaccine to target malaria.
The Germany-based company, which developed the first widely approved coronavirus shot together with U.S. partner Pfizer, aims to begin clinical trials for a "safe and highly effective malaria vaccine" by the end of next year.
"We are already working on HIV and and tuberculosis, and malaria is the third big indication (disease) with a high unmet medical need," BioNTech's chief executive, Ugur Sahin, told The Associated Press. "It has an incredible high number of people being infected every year, a high number of patients dying, a particularly severe disease and high mortality in small children."
According to the World Health Organization, there were about 229 million cases of malaria worldwide in 2019. The global body estimates that 409,000 people died from malaria that year, with children under the age of 5 accounting for 67% of deaths.
Africa has by far the highest burden of the mosquito-borne disease worldwide, WHO says.
Sahin acknowledged that the effort is at a very early stage and there's no guarantee of success. But he said the company believes it's "the perfect time to address this challenge" because of the insights it has gained from developing an mRNA vaccine against the coronavirus and a growing understanding of how malaria works.
Experts say developing a vaccine to prime the immune system against malaria will be tricky, however.
"The genome of Plasmodium, the parasite that causes malaria, is more complex than viruses," said Prakash Srinivasan, an assistant professor at Johns Hopkins Bloomberg School of Public Health.
A malaria vaccine made by drugmaker GlaxoSmithKline already being trialed in three African countries has shown that inducing strong, long-lasting antibody levels is challenging, he said.
Existing and future variants of the parasite could also pose a challenge to developing an effective vaccine, said Srinivasan, whose lab is also working to develop a shot against malaria.
But Barton Haynes, director of the Duke Human Vaccine Institute, said the experience of the COVID-19 pandemic showed mRNA technology could be used to quickly adapt vaccines to work against new variants.
"The mRNA platform is going to be applicable to many different pathogens," he said.
Sahin said early-stage development and testing of vaccines normally costs about $30-80 million.
The project, which is a collaboration with the World Health Organization, the European Commission and the Bill and Melinda Gates Foundation, "has no budget limits at the moment," he added.
BioNTech said it is also seeking to establish an mRNA vaccine production facility in Africa, which is among the regions that have struggled to get sufficient supply of COVID-19 vaccine doses.
The company said it is working with partners to "evaluate how to establish sustainable mRNA manufacturing capabilities on the African continent to supply African countries with vaccines." Once built, such a facility would be able to make various mRNA-based vaccines.
BioNTech and Pfizer have said they will deliver 1 billion doses of their COVID-19 vaccine to middle- and low-income countries this year, and another billion doses in 2022.
Last week, the two companies announced that a South African firm, the Biovac Institute, will become the first on the continent to start producing their coronavirus vaccine.
BioNTech has previously said it is working on a vaccine candidate for tuberculosis, with clinical trials aimed for 2022, and therapies for several forms of cancer.
The widow of a Quebec man who died competing in an Ironman competition is looking for answers.
Former NDP leader Tom Mulcair says that what's happening now in a trash-littered federal park in Quebec is a perfect metaphor for how the Trudeau government runs things.
The world is seeing a near breakdown of international law amid flagrant rule-breaking in Gaza and Ukraine, multiplying armed conflicts, the rise of authoritarianism and huge rights violations in Sudan, Ethiopia and Myanmar, Amnesty International warned Wednesday as it published its annual report.
A photographer who worked for Megan Thee Stallion said in a lawsuit filed Tuesday that he was forced to watch her have sex, was unfairly fired soon after and was abused as her employee.
Facing pushback from physicians and businesspeople over the coming increase to the capital gains inclusion rate, Prime Minister Justin Trudeau and his deputy Chrystia Freeland are standing by their plan to target Canada's highest earners.
The Senate passed legislation Tuesday that would force TikTok's China-based parent company to sell the social media platform under the threat of a ban, a contentious move by U.S. lawmakers that's expected to face legal challenges.
People living near a wildfire burning about 15 kilometres southwest of Peace River are being told to evacuate their homes.
The U.S. Senate has passed US$95 billion in war aid to Ukraine, Israel and Taiwan, sending the legislation to President Joe Biden after months of delays and contentious debate over how involved the United States should be in foreign wars.
A Winnipeg man said a single date gone wrong led to years of criminal harassment, false arrests, stress and depression.
The giant stone statues guarding the Lions Gate Bridge have been dressed in custom Vancouver Canucks jerseys as the NHL playoffs get underway.
A local Oilers fan is hoping to see his team cut through the postseason, so he can cut his hair.
A family from Laval, Que. is looking for answers... and their father's body. He died on vacation in Cuba and authorities sent someone else's body back to Canada.
A former educational assistant is calling attention to the rising violence in Alberta's classrooms.
The federal government says its plan to increase taxes on capital gains is aimed at wealthy Canadians to achieve “tax fairness.”
At 6'8" and 350 pounds, there is nothing typical about UBC offensive lineman Giovanni Manu, who was born in Tonga and went to high school in Pitt Meadows.
Kevin the cat has been reunited with his family after enduring a harrowing three-day ordeal while lost at Toronto Pearson International Airport earlier this week.
Molly Knight, a Grade 4 student in Nova Scotia, noticed her school library did not have many books on female athletes, so she started her own book drive in hopes of changing that.
Almost 7,000 bars of pure gold were stolen from Pearson International Airport exactly one year ago during an elaborate heist, but so far only a tiny fraction of that stolen loot has been found.