COVID-19 vaccines made by Pfizer and Moderna that use mRNA technology provide the biggest boost to antibody levels when given 10-12 weeks after the second dose, a new British study has found.
The "COV-Boost" study was cited by British officials when they announced that Pfizer and Moderna were preferred for use in the country's booster campaign, but the data has only been made publicly available now.
The study found that six of the seven boosters examined enhanced immunity after initial vaccination with Pfizer-BioNTech's vaccine, while all seven increased immunity when given after two doses of AstraZeneca's vaccine.
"A third dose will be effective for many of the vaccines we've tested and in many different combinations," Professor Saul Faust, an immunologist at the University of Southampton and the trial's lead, told reporters.
The study, published late on Thursday, found that a full dose or half dose of Pfizer or a full dose of Moderna gave a strong boost to both antibody and T-cell levels, regardless of whether the person initially received Pfizer or AstraZeneca.
"All four of the vaccination regimes most widely deployed in the U.K. lead to essentially the same levels of immunity and are likely to be equally effective," said Professor Eleanor Riley, immunologist at the University of Edinburgh. She added that a policy change in booster gaps was also supported by the data.
"These data support the JCVI (vaccine committee) decision earlier this week to bring forward booster doses to 3 months after the second vaccination."
When AstraZeneca, Novavax, Johnson & Johnson and Curevac were given as boosters, they increased antibody levels for either initial vaccine, albeit to a smaller degree, the study found. However, while Valneva boosted antibodies in people initially vaccinated with AstraZeneca, it did not provide a boost for Pfizer.
The COV-Boost study pre-dated the spread of the emergent Omicron variant of concern, and Faust said he had shared samples with the UK Health Security Agency to generate data on Omicron.
The study did however find that booster shots also helped to generate a broad T-cell response against the Beta and Delta variants, which may play a key role in longer-term protection.
A separate study by Imperial College London into how initial exposure to SARS-CoV-2 shapes immune responses, also published late on Thursday, similarly found a good T-cell response to both Alpha and Delta after infection followed by vaccination.
(Reporting by Alistair Smout; Editing by Bernadette Baum and Mark Heinrich)
Canadians will learn Tuesday the entirety of the federal Liberal government's new spending plans, and how they intend to pay for them, when Deputy Prime Minister and Finance Minister Chrystia Freeland tables the 2024 federal budget.
An Ontario woman was shocked to find she’d been charged nearly $7,000 after unknowingly using an unauthorized taxi company while on vacation in January.
A man is fighting for his life after falling about 30 feet in an air duct at Montreal's Olympic Stadium on Monday, authorities say.
Tim Hortons is launching flatbread pizzas nationally in a bid to pick up more afternoon and evening customers.
The National Capital Commission is providing a glimpse inside the gutted 24 Sussex Drive, more than a year after the heritage building along the Ottawa River was closed.
NASA confirmed Monday that a mystery object that crashed through the roof of a Florida home last month was a chunk of space junk from equipment discarded at the International Space Station.
Without having seen it, former Bank of Canada governor David Dodge believes that Tuesday's 2024 federal budget from Deputy Prime Minister and Finance Minister Chrystia Freeland is 'likely to be the worst budget' in decades.
Using genes from coffee plants around the world, researchers built a family tree for the world's most popular type of coffee, known to scientists as Coffea arabica and to coffee lovers simply as 'arabica.'
Here's a look at the workings and meaning of the elaborate flame-lighting ceremony held among the ruins of Ancient Olympia ahead of each modern Olympiad.
Ontario Provincial Police are investigating after human remains were found in the Ottawa River in Clarence-Rockland on Monday.
A mass exodus of elected officials from a rural Manitoba municipality has put the community in limbo and may force the province to dissolve what's left of the crumbling council.
A man is fighting for his life after falling about 30 feet in an air duct at Montreal's Olympic Stadium on Monday, authorities say.
Saskatchewan and the RCMP have inked a deal that would see the province fund hundreds more officers if Mounties can recruit to fill those positions.
An Ontario woman was shocked to find she’d been charged nearly $7,000 after unknowingly using an unauthorized taxi company while on vacation in January.
An agreement between the provincial and federal governments will see Premier Doug Ford’s flagship Highway 413 move forward with a joint working group dedicated to minimizing environmental impacts.
A fire raged through one of Copenhagen's oldest buildings on Tuesday, causing the collapse of the iconic spire from the 17th-century Old Stock Exchange as passersby rushed to help emergency services save priceless paintings and other valuables.
Following the Iranian missile and drone strikes against Israel over the weekend, Canada should take the threat of Iran and potential escalation of the conflict seriously, one global affairs analyst says.
A couple who owned a Colorado funeral home where authorities last year discovered 190 decaying bodies were indicted on federal charges that they misspent nearly US$900,000 in pandemic relief funds on vacations, cosmetic surgery, jewelry and other personal expenses, according to court documents unsealed Monday.
The ship crash that destroyed Baltimore’s Francis Scott Key Bridge and left several people dead is now under federal criminal investigation, according to a U.S. official familiar with the matter.
The historic hush-money trial of Donald Trump got underway Monday with the arduous process of selecting a jury to hear the case charging the former U.S. president with falsifying business records in order to stifle stories about his sex life.
The U.S. Supreme Court on Monday let a Republican-backed law in Idaho that criminalizes gender-affirming care for transgender minors broadly take effect after a federal judge blocked it as unconstitutional.
Canadians will learn Tuesday the entirety of the federal Liberal government's new spending plans, and how they intend to pay for them, when Deputy Prime Minister and Finance Minister Chrystia Freeland tables the 2024 federal budget.
Foreign Affairs Minister Mélanie Joly says she's urging Israel to de-escalate rising conflicts in the Middle East and not bomb Iran in retaliation for this past weekend's thwarted airstrikes.
The federal leader of the New Democrats is insisting his party's position on carbon pricing remains unchanged.
Functional beverages -- or drinks promoted as offering mental or physical benefits beyond hydration -- are growing in popularity around the world. Hundreds of companies have jumped into the market, hoping to get some buzz with trendy and sometimes unfamiliar ingredients.
Difficulties hiring and retaining enough nurses and personal support workers for long-term care homes could mean the Ontario government may not meet its target for the amount of hands-on care residents receive, the minister responsible for the sector was warned.
It’s common knowledge that exercise is good for your mental health and your heart health — and now a new study suggests that all three are working together.
NASA confirmed Monday that a mystery object that crashed through the roof of a Florida home last month was a chunk of space junk from equipment discarded at the International Space Station.
Using genes from coffee plants around the world, researchers built a family tree for the world's most popular type of coffee, known to scientists as Coffea arabica and to coffee lovers simply as 'arabica.'
NASA is seeking innovative methods that could help retrieve samples collected by the Perseverance rover on Mars in the future.
Dyson Knight may look like an average college student, but since 2004, he’s actually been a member of the internationally acclaimed Baha Men.
Canadian singer Grimes apologized to fans on Saturday after her Coachella set earlier that evening was beset by technical issues that caused her to scream into the microphone in frustration.
A movie weapons supervisor was sentenced to 18 months in prison in the fatal shooting of a cinematographer by Alec Baldwin on the set of 'Rust.'
Tim Hortons is launching flatbread pizzas nationally in a bid to pick up more afternoon and evening customers.
A Vancouver woman whose company duped investors by promising big returns on real-estate deals that would house the homeless has been ordered to pay nearly $626,000 after the British Columbia Securities Commission deemed the operation a Ponzi scheme.
The U.S. Department of Justice is preparing to file an antitrust lawsuit against Live Nation as soon as next month, the Wall Street Journal reported on Monday, citing people familiar with the matter.
A high score on a Foo Fighters pinball machine has Edmonton player Dave Formenti on a high.
Celebrity food critic Keith Lee said he was blown away by Toronto, handing a rich ranking to its culinary creators, as the first international stop of his latest food tour.
Even as the cost of living goes up, there are still ways to save some cash when out shopping or using credit cards.
Here's a look at the workings and meaning of the elaborate flame-lighting ceremony held among the ruins of Ancient Olympia ahead of each modern Olympiad.
After four years at the University of Connecticut, Edwards was selected sixth overall by the Washington Mystics in the WNBA draft Monday night.
The Indiana Fever selected sharpshooter Caitlin Clark with the first pick of the WNBA Draft on Monday.
General Motors will move its Detroit headquarters to a new downtown office building next year and work to redevelop its iconic home along the Detroit River, company and city officials confirmed Monday.
Tesla will lay off more than 10 per cent of its global workforce, an internal memo seen by Reuters on Monday shows, as it grapples with falling sales amid an intensifying price war for electric vehicles.
Looking for a break on car insurance premiums is often top of mind for drivers. And finding ways to reduce that figure is especially important now, when rampant thefts have led to higher insurance costs.
While many people choose to keep their medical appointments private, four longtime friends decided to undergo vasectomies as a group in B.C.'s Lower Mainland.
A popular highway in Alberta's Banff National Park now has a 'no stopping zone' to help protect two bears.
B.C. resident Robert Conrad spent thousands of hours on Crown land developing an unusual bond with deer.
A Sudbury woman said her husband was bringing the recycling out to the curb Wednesday night when he had to make a 'mad dash' inside after seeing a bear.
A school teacher who took part in the Quebec version of the Survivor reality TV show took time off work to be a contestant is now out of a job.
A young actor from Prince Edward Island is getting the chance to fulfill a childhood dream, playing the precocious and iconic Anne Shirley on stage.
Nicholas Zhang, 17, will be competing at the Paris Olympics in July. He is the youngest Canadian male fencer to ever compete in the category.
For many, Monday's total solar eclipse will become a distant memory or collection of photos to scroll through in the years to come. But for Alannah Duarte and her family, they'll be reminded of the rare celestial event every year they celebrate their youngest son's birthday, as he was born on the day of the momentous occasion.
A Montreal couple is having a hard time driving without stress and is unhappy with the city's maintenance after a chunk of highway crashed into their windshield while driving on Thursday night.
The family of a Victoria, B.C., woman who was seriously injured in an accident in Thailand is pleading for help as medical bills pile up.
Last summer, Jessica Michalofsky ran from Nelson to Victoria, raising awareness about the toxic drug crisis that claimed her son Aubrey’s life. Nearly a year later, she's disappointed by the lack of movement on the crisis, as more families lose loved ones.
A Vancouver real estate services firm is pushing back against the widely held view that not enough homes are being built in Metro Vancouver.
An Ontario woman was shocked to find she’d been charged nearly $7,000 after unknowingly using an unauthorized taxi company while on vacation in January.
Some flights may be departing from Toronto Pearson International Airport with “less or no food” after workers who prepare meals for in-flight service walked off the job on Tuesday, the union representing employees says.
Tim Hortons is launching flatbread pizzas nationally in a bid to pick up more afternoon and evening customers.
Alberta legislation pitched to protect provincial priorities could slow down grant funding and allow federal money to be spent elsewhere, say officials representing rural municipalities and faculty members at post-secondary institutions.
A young Okotoks, Alta., family is preparing for a long year ahead, as the first of their two children begins a stem cell transplant they hope will prolong her life.
The cradle is an anonymous drop-off site where an infant can be left in a heated, secured bed, signalling a silent alarm which informs staff.
Ontario Provincial Police are investigating after human remains were found in the Ottawa River in Clarence-Rockland on Monday.
A recent initiative out of CHEO's YouthNet program is working to destigmatize mental illness in the younger generation.
After four years at the University of Connecticut, Edwards was selected sixth overall by the Washington Mystics in the WNBA draft Monday night.
An international competition is hoping to gather new and interesting ways to recycle Montreal's Olympic Stadium roof, which is set to be dismantled this summer.
Linda Simard says her husband frantically told her to call 911 as he watched two volunteer firefighters get swept away in rushing floodwaters in Quebec's Charlevoix region last year.
A man is fighting for his life after falling about 30 feet in an air duct at Montreal's Olympic Stadium on Monday, authorities say.
Two tickets were issued after an unleashed dog was seen in front of a home where a boy died in a dog attack earlier this month.
In an exclusive interview with CTV News Edmonton on Monday, the premier said a study out of the United Kingdom, the Cass Review, echoes some of her concerns in regards to a lack of scientific rigor when it comes to puberty blockers.
The Alberta government is offering a 7.5-per-cent wage increase in the midst of collective bargaining, with government workers calling for a 26-per-cent bump.
Canadians will learn Tuesday the entirety of the federal Liberal government's new spending plans, and how they intend to pay for them, when Deputy Prime Minister and Finance Minister Chrystia Freeland tables the 2024 federal budget.
Police are looking for a youth who allegedly stabbed another youth in Halifax on Monday morning.
A low pressure system brought a series of weather fronts across the Maritimes on Friday and into the start of the weekend.
A mass exodus of elected officials from a rural Manitoba municipality has put the community in limbo and may force the province to dissolve what's left of the crumbling council.
An approaching low-pressure system that could bring 50 millimetres of mixed precipitation has triggered a flood warning for parts of Manitoba.
If you’ve ever felt the allure of Hollywood and wanted to be in a big-budget movie your time to shine is now.
Moose Jaw's hyperbaric chamber has now partially resumed services after being discontinued in 2021 due pandemic related staffing shortages. However, only one patient is currently being treated leading to criticism over a perceived lack of service.
Michael Gordon Jackson, the man on trial after being charged with contravention of a custody order for allegedly abducting his daughter in late 2021 to prevent her from getting a COVID-19 vaccine, called himself to the stand Monday.
Regina's Jon Ryan is set to sign a one-day contract with the Seattle Seahawks tomorrow officially bringing to an end his pro-football career.
Cambridge resident Samantha Falkiner explains why something felt "off" about the men who approached her and her neighbours on Friday.
Police are searching a residence just east of downtown Guelph after a man went to hospital with injuries from a homemade explosive device.
Wellington County OPP is currently investigating a double fatal collision near Drayton.
Friends are raising money for the grieving family of a 16-year-old Saskatoon boy who was killed in a high-speed crash that injured two other teens on Sunday morning.
Dr. Ana-Maria Bosonea is the only allergist in Saskatoon seeing children under 12, and now she’s moving to Alberta.
The city says there may be some odour emanating from the landfill in the coming weeks as crews dig new gas wells and piping to collect more methane from decomposing waste.
An Ontario woman was shocked to find she’d been charged nearly $7,000 after unknowingly using an unauthorized taxi company while on vacation in January.
A northern Ontario family is devastated after a jury found a Moose Factory man not guilty of a 2021 murder.
The body of a 14-year-old boy has been pulled from Lake Ontario after police say he drowned while swimming near Ashbridges Bay Park on Sunday night.
A number of students have been displaced after a house fire in east London near Fanshawe College. Crews were called to the scene on Prosperity Court late Monday night.
A massive surplus remains from last year’s municipal budget in London, but city staff warned councillors against using it for a tax break this year.
Cigarette butts remain the most littered item in the world — including London. On Monday, a ‘butt blitz’ was held behind city hall in Reg Cooper Square.
The residents of Kashechewan First Nation are in a race against time, preparing for a mass evacuation as the relentless threat of flooding from the Albany River looms closer.
It's been more than two years since Jim Lynne died in a crash along Mosley Street in Wasaga Beach.
A street sign in Barrie, renamed to honour 11-year-old Chase McEachern's legacy after he died in 2006, has gone missing again from an alleyway at the heart of the city's waterfront.
General Motors will move its Detroit headquarters to a new downtown office building next year and work to redevelop its iconic home along the Detroit River, company and city officials confirmed Monday.
Windsor police are looking for a woman after a parcel was taken from a home in the 400 block of Chilver Road.
The first Canadian tornado of 2024 hit Essex County in March, says a report from the Northern Tornadoes Project.
The family of a Victoria, B.C., woman who was seriously injured in an accident in Thailand is pleading for help as medical bills pile up.
A Vancouver woman whose company duped investors by promising big returns on real-estate deals that would house the homeless has been ordered to pay nearly $626,000 after the British Columbia Securities Commission deemed the operation a Ponzi scheme.
The HMCS Max Bernays made its way into its new home at CFB Esquimalt on Monday after a long journey from Halifax.
British Columbia is planning to add 240 new units to its complex-care housing program, providing homes for people with mental-health and addictions challenges that overlap with other serious conditions.
More than 80 residents from a low-income apartment building in Kelowna, B.C., have learned they won't be able to return to their homes for at least another two weeks.
Mounties are investigating a reported "road rage" incident in Kelowna, B.C., that left two men injured last week.
Lethbridge West MLA Shannon Phillips is calling on the province to reinstate funding for the Lethbridge Elder Abuse Response Network.
If you’re planning to head to the coulees this weekend to enjoy the nice weather, don’t forget to look down.
With the weather starting to feel like spring is really here, more kids will likely be outside enjoying the sunshine and warm temperatures, which organizers of the Slow Your Roll campaign say is a perfect time to re-launch the campaign.
The City of Sault Ste. Marie is expecting a busy summer at the Downtown Plaza. City officials say the plaza is coming off a successful first winter season, which saw large crowds gathering at the outdoor rink.
The Soo Greyhounds are the talk of the town, as their second-round matchup in the OHL playoffs touches down in the Sault.
Thunder Bay Police Service held a news conference Monday afternoon to discuss the misconduct investigation that led to criminal charges being laid against the city's former police chief.
A pricing agreement has been reached between crab fishers and seafood processors that will allow for Newfoundland and Labrador's annual crab fishery to get started.
Longliners across Newfoundland and Labrador are tied up once again, as a new protest by the province's fish harvesters threatens to derail the crab fishery for a second straight year.
A unique photo exhibit is putting cameras into the hands of survivors of domestic and sexual violence in Newfoundland and Labrador.
The Shopping Trends team is independent of the journalists at CTV News. We may earn a commission when you use our links to shop. Read about us.
