Researchers at Oxford University said on Thursday they have developed a method to predict the efficacy of new COVID-19 vaccines based on a blood test, potentially offering a short-cut around massive clinical trials that are increasingly difficult to conduct.
The researchers looked at the concentration of a range of virus-fighting antibodies in the blood of trial participants after they had received the vaccine developed by AstraZeneca and Oxford University, now known as Vaxzevria.
By looking at which of those trial volunteers later contracted symptomatic COVID-19 and which did not, the researchers came up with a model they hope will predict how powerful other vaccines will be, based on those blood readings.
"The data can be used to extrapolate efficacy estimates for new vaccines where large efficacy trials cannot be conducted," they said in their paper, which was posted online on Thursday and submitted for peer-review for future publication in a scientific journal.
The Oxford researchers cautioned more work was needed to validate their model for many of the highly contagious new virus variants of concern.
They noted that they did not look into the so-called cellular immune response, a major weapon of the human body against infections alongside antibodies, but more difficult to measure.
"There is an urgent need to increase supply of vaccines for the world, but development and approval of new vaccines takes many months. We hope that the use of correlates by developers and regulators could speed up the process," said Andrew Pollard, Director of the Oxford Vaccine Group and lead investigator on the Oxford Vaccine Trial.
Researchers and regulators around the globe are working on such benchmarks – known as a correlates of protection or surrogate endpoints - which may allow laggards in the vaccine development race to provide evidence of efficacy without having to conduct trials with tens of thousands of volunteers.
Those mass trials have so far relied on participants to contract the disease in their normal lives to provide vaccine efficacy results. That becomes more of a challenge where vaccination coverage is already high and the virus is not circulating widely.
The traditional clinical trials also require many participants to get a placebo as a comparison to those who receive the experimental vaccine, posing an ethical dilemma where approved shots are available.
(Reporting by Ludwig Burger Editing by Bill Berkrot)
Canadians will learn Tuesday the entirety of the federal Liberal government's new spending plans, and how they intend to pay for them, when Deputy Prime Minister and Finance Minister Chrystia Freeland tables the 2024 federal budget.
An Ontario woman was shocked to find she’d been charged nearly $7,000 after unknowingly using an unauthorized taxi company while on vacation in January.
A man is fighting for his life after falling about 30 feet in an air duct at Montreal's Olympic Stadium on Monday, authorities say.
Tim Hortons is launching flatbread pizzas nationally in a bid to pick up more afternoon and evening customers.
The flame that is to burn at the Paris Olympics was kindled Tuesday at the site of the ancient games in southern Greece.
While many celebrity homes look less than lived-in, ranging from spotless minimal to ostentatiously palatial, actor Emma Roberts' Hollywood Hills home is made for curling up with a good book -- or several -- with warm tones, comfortable couches, and antique curiosities in each room (also, a lagoon-style pool in the backyard for summer reads).
NASA confirmed Monday that a mystery object that crashed through the roof of a Florida home last month was a chunk of space junk from equipment discarded at the International Space Station.
Tesla has hit a series of roadblocks, including increased competition and declining sales. The company announced Monday it is slashing 10 per cent of its global workforce.
A fire raged through one of Copenhagen's oldest buildings on Tuesday, causing the collapse of the iconic spire from the 17th-century Old Stock Exchange as passersby rushed to help emergency services save priceless paintings and other valuables.
Ontario Provincial Police are investigating after human remains were found in the Ottawa River in Clarence-Rockland on Monday.
A mass exodus of elected officials from a rural Manitoba municipality has put the community in limbo and may force the province to dissolve what's left of the crumbling council.
A man is fighting for his life after falling about 30 feet in an air duct at Montreal's Olympic Stadium on Monday, authorities say.
Saskatchewan and the RCMP have inked a deal that would see the province fund hundreds more officers if Mounties can recruit to fill those positions.
An Ontario woman was shocked to find she’d been charged nearly $7,000 after unknowingly using an unauthorized taxi company while on vacation in January.
An agreement between the provincial and federal governments will see Premier Doug Ford’s flagship Highway 413 move forward with a joint working group dedicated to minimizing environmental impacts.
A fire raged through one of Copenhagen's oldest buildings on Tuesday, causing the collapse of the iconic spire from the 17th-century Old Stock Exchange as passersby rushed to help emergency services save priceless paintings and other valuables.
A teenager has been accused of wounding a Christian bishop and priest during a church service in a second high-profile knife attack to rock Sydney in recent days, leaving communities on edge, leaders calling for calm and a besieged church urging against retaliation.
German Chancellor Olaf Scholz told Chinese leader Xi Jinping who hosted him in Beijing on Tuesday that Russia's full-scale invasion of Ukraine threatens global security, in an apparent call for China to apply greater pressure on its neighbour and close strategic partner to resolve the conflict.
Following the Iranian missile and drone strikes against Israel over the weekend, Canada should take the threat of Iran and potential escalation of the conflict seriously, one global affairs analyst says.
A couple who owned a Colorado funeral home where authorities last year discovered 190 decaying bodies were indicted on federal charges that they misspent nearly US$900,000 in pandemic relief funds on vacations, cosmetic surgery, jewelry and other personal expenses, according to court documents unsealed Monday.
The ship crash that destroyed Baltimore’s Francis Scott Key Bridge and left several people dead is now under federal criminal investigation, according to a U.S. official familiar with the matter.
Canadians will learn Tuesday the entirety of the federal Liberal government's new spending plans, and how they intend to pay for them, when Deputy Prime Minister and Finance Minister Chrystia Freeland tables the 2024 federal budget.
Foreign Affairs Minister Mélanie Joly says she's urging Israel to de-escalate rising conflicts in the Middle East and not bomb Iran in retaliation for this past weekend's thwarted airstrikes.
The federal leader of the New Democrats is insisting his party's position on carbon pricing remains unchanged.
Functional beverages -- or drinks promoted as offering mental or physical benefits beyond hydration -- are growing in popularity around the world. Hundreds of companies have jumped into the market, hoping to get some buzz with trendy and sometimes unfamiliar ingredients.
Difficulties hiring and retaining enough nurses and personal support workers for long-term care homes could mean the Ontario government may not meet its target for the amount of hands-on care residents receive, the minister responsible for the sector was warned.
It’s common knowledge that exercise is good for your mental health and your heart health — and now a new study suggests that all three are working together.
NASA confirmed Monday that a mystery object that crashed through the roof of a Florida home last month was a chunk of space junk from equipment discarded at the International Space Station.
Using genes from coffee plants around the world, researchers built a family tree for the world's most popular type of coffee, known to scientists as Coffea arabica and to coffee lovers simply as 'arabica.'
NASA is seeking innovative methods that could help retrieve samples collected by the Perseverance rover on Mars in the future.
While many celebrity homes look less than lived-in, ranging from spotless minimal to ostentatiously palatial, actor Emma Roberts' Hollywood Hills home is made for curling up with a good book -- or several -- with warm tones, comfortable couches, and antique curiosities in each room (also, a lagoon-style pool in the backyard for summer reads).
Canadian singer Grimes apologized to fans on Saturday after her Coachella set earlier that evening was beset by technical issues that caused her to scream into the microphone in frustration.
A movie weapons supervisor was sentenced to 18 months in prison in the fatal shooting of a cinematographer by Alec Baldwin on the set of 'Rust.'
Statistics Canada will release its consumer price index for March on inflation this morning.
Tim Hortons is launching flatbread pizzas nationally in a bid to pick up more afternoon and evening customers.
A Vancouver woman whose company duped investors by promising big returns on real-estate deals that would house the homeless has been ordered to pay nearly $626,000 after the British Columbia Securities Commission deemed the operation a Ponzi scheme.
A high score on a Foo Fighters pinball machine has Edmonton player Dave Formenti on a high.
Celebrity food critic Keith Lee said he was blown away by Toronto, handing a rich ranking to its culinary creators, as the first international stop of his latest food tour.
Even as the cost of living goes up, there are still ways to save some cash when out shopping or using credit cards.
Connor McDavid achieved a rare feat as his team was administering a rare beating.
Here's a look at the workings and meaning of the elaborate flame-lighting ceremony held among the ruins of Ancient Olympia ahead of each modern Olympiad.
The flame that is to burn at the Paris Olympics was kindled Tuesday at the site of the ancient games in southern Greece.
General Motors will move its Detroit headquarters to a new downtown office building next year and work to redevelop its iconic home along the Detroit River, company and city officials confirmed Monday.
Nissan expects to mass produce electric vehicles powered by advanced next-generation batteries by early 2029, the company said Tuesday during a media tour of an unfinished pilot plant.
Tesla will lay off more than 10 per cent of its global workforce, an internal memo seen by Reuters on Monday shows, as it grapples with falling sales amid an intensifying price war for electric vehicles.
While many people choose to keep their medical appointments private, four longtime friends decided to undergo vasectomies as a group in B.C.'s Lower Mainland.
A popular highway in Alberta's Banff National Park now has a 'no stopping zone' to help protect two bears.
B.C. resident Robert Conrad spent thousands of hours on Crown land developing an unusual bond with deer.
A Sudbury woman said her husband was bringing the recycling out to the curb Wednesday night when he had to make a 'mad dash' inside after seeing a bear.
A school teacher who took part in the Quebec version of the Survivor reality TV show took time off work to be a contestant is now out of a job.
A young actor from Prince Edward Island is getting the chance to fulfill a childhood dream, playing the precocious and iconic Anne Shirley on stage.
Nicholas Zhang, 17, will be competing at the Paris Olympics in July. He is the youngest Canadian male fencer to ever compete in the category.
For many, Monday's total solar eclipse will become a distant memory or collection of photos to scroll through in the years to come. But for Alannah Duarte and her family, they'll be reminded of the rare celestial event every year they celebrate their youngest son's birthday, as he was born on the day of the momentous occasion.
A Montreal couple is having a hard time driving without stress and is unhappy with the city's maintenance after a chunk of highway crashed into their windshield while driving on Thursday night.
The family of a Victoria, B.C., woman who was seriously injured in an accident in Thailand is pleading for help as medical bills pile up.
Last summer, Jessica Michalofsky ran from Nelson to Victoria, raising awareness about the toxic drug crisis that claimed her son Aubrey’s life. Nearly a year later, she's disappointed by the lack of movement on the crisis, as more families lose loved ones.
A Vancouver real estate services firm is pushing back against the widely held view that not enough homes are being built in Metro Vancouver.
An Ontario woman was shocked to find she’d been charged nearly $7,000 after unknowingly using an unauthorized taxi company while on vacation in January.
Some flights may be departing from Toronto Pearson International Airport with “less or no food” after workers who prepare meals for in-flight service walked off the job on Tuesday, the union representing employees says.
Tim Hortons is launching flatbread pizzas nationally in a bid to pick up more afternoon and evening customers.
Alberta legislation pitched to protect provincial priorities could slow down grant funding and allow federal money to be spent elsewhere, say officials representing rural municipalities and faculty members at post-secondary institutions.
Canadians will learn Tuesday the entirety of the federal Liberal government's new spending plans, and how they intend to pay for them, when Deputy Prime Minister and Finance Minister Chrystia Freeland tables the 2024 federal budget.
A young Okotoks, Alta., family is preparing for a long year ahead, as the first of their two children begins a stem cell transplant they hope will prolong her life.
Canadians will learn Tuesday the entirety of the federal Liberal government's new spending plans, and how they intend to pay for them, when Deputy Prime Minister and Finance Minister Chrystia Freeland tables the 2024 federal budget.
Ontario Provincial Police are investigating after human remains were found in the Ottawa River in Clarence-Rockland on Monday.
After four years at the University of Connecticut, Edwards was selected sixth overall by the Washington Mystics in the WNBA draft Monday night.
An international competition is hoping to gather new and interesting ways to recycle Montreal's Olympic Stadium roof, which is set to be dismantled this summer.
The Montreal Canadiens have recalled defenceman Logan Mailloux from the AHL's Laval Rocket.
Quebec City police say three people were arrested in connection with an alleged assault in the Beauport borough.
Two tickets were issued after an unleashed dog was seen in front of a home where a boy died in a dog attack earlier this month.
Connor McDavid achieved a rare feat as his team was administering a rare beating.
Canadians will learn Tuesday the entirety of the federal Liberal government's new spending plans, and how they intend to pay for them, when Deputy Prime Minister and Finance Minister Chrystia Freeland tables the 2024 federal budget.
Batteries power many things in our lives, from phones to laptops to even cars, but there’s a danger lurking in our battery dependency.
Canadians will learn Tuesday the entirety of the federal Liberal government's new spending plans, and how they intend to pay for them, when Deputy Prime Minister and Finance Minister Chrystia Freeland tables the 2024 federal budget.
Police are looking for a youth who allegedly stabbed another youth in Halifax on Monday morning.
A mass exodus of elected officials from a rural Manitoba municipality has put the community in limbo and may force the province to dissolve what's left of the crumbling council.
An approaching low-pressure system that could bring 50 millimetres of mixed precipitation has triggered a flood warning for parts of Manitoba.
If you’ve ever felt the allure of Hollywood and wanted to be in a big-budget movie your time to shine is now.
Moose Jaw's hyperbaric chamber has now partially resumed services after being discontinued in 2021 due pandemic related staffing shortages. However, only one patient is currently being treated leading to criticism over a perceived lack of service.
Michael Gordon Jackson, the man on trial after being charged with contravention of a custody order for allegedly abducting his daughter in late 2021 to prevent her from getting a COVID-19 vaccine, called himself to the stand Monday.
Regina's Jon Ryan is set to sign a one-day contract with the Seattle Seahawks tomorrow officially bringing to an end his pro-football career.
Ontario Provincial Police (OPP) are asking some people in Delhi to stay in their homes as officers conduct an investigation.
Cambridge resident Samantha Falkiner explains why something felt "off" about the men who approached her and her neighbours on Friday.
Police are searching a residence just east of downtown Guelph after a man went to hospital with injuries from a homemade explosive device.
Friends are raising money for the grieving family of a 16-year-old Saskatoon boy who was killed in a high-speed crash that injured two other teens on Sunday morning.
Dr. Ana-Maria Bosonea is the only allergist in Saskatoon seeing children under 12, and now she’s moving to Alberta.
The city says there may be some odour emanating from the landfill in the coming weeks as crews dig new gas wells and piping to collect more methane from decomposing waste.
An Ontario woman was shocked to find she’d been charged nearly $7,000 after unknowingly using an unauthorized taxi company while on vacation in January.
A northern Ontario family is devastated after a jury found a Moose Factory man not guilty of a 2021 murder.
The body of a 14-year-old boy has been pulled from Lake Ontario after police say he drowned while swimming near Ashbridges Bay Park on Sunday night.
All lanes of traffic have reopened after a vehicle struck a fire hydrant in Sarnia on Monday. It happened in the area of Michigan Avenue and Blackwell Road and caused officials to reduce eastbound traffic to one lane.
A number of students have been displaced after a house fire in east London near Fanshawe College. Crews were called to the scene on Prosperity Court late Monday night.
A massive surplus remains from last year’s municipal budget in London, but city staff warned councillors against using it for a tax break this year.
The residents of Kashechewan First Nation are in a race against time, preparing for a mass evacuation as the relentless threat of flooding from the Albany River looms closer.
Two women were seriously injured after a car crash in Orangeville.
It's been more than two years since Jim Lynne died in a crash along Mosley Street in Wasaga Beach.
Windsor police are looking for a woman after a parcel was taken from a home in the 400 block of Chilver Road.
The first Canadian tornado of 2024 hit Essex County in March, says a report from the Northern Tornadoes Project.
A new ranking by food delivery platform Uber Eats puts Windsor among the top cities in the province for ordering cannabis.
The family of a Victoria, B.C., woman who was seriously injured in an accident in Thailand is pleading for help as medical bills pile up.
A Vancouver woman whose company duped investors by promising big returns on real-estate deals that would house the homeless has been ordered to pay nearly $626,000 after the British Columbia Securities Commission deemed the operation a Ponzi scheme.
The HMCS Max Bernays made its way into its new home at CFB Esquimalt on Monday after a long journey from Halifax.
British Columbia is planning to add 240 new units to its complex-care housing program, providing homes for people with mental-health and addictions challenges that overlap with other serious conditions.
More than 80 residents from a low-income apartment building in Kelowna, B.C., have learned they won't be able to return to their homes for at least another two weeks.
Mounties are investigating a reported "road rage" incident in Kelowna, B.C., that left two men injured last week.
Lethbridge West MLA Shannon Phillips is calling on the province to reinstate funding for the Lethbridge Elder Abuse Response Network.
If you’re planning to head to the coulees this weekend to enjoy the nice weather, don’t forget to look down.
With the weather starting to feel like spring is really here, more kids will likely be outside enjoying the sunshine and warm temperatures, which organizers of the Slow Your Roll campaign say is a perfect time to re-launch the campaign.
The City of Sault Ste. Marie is expecting a busy summer at the Downtown Plaza. City officials say the plaza is coming off a successful first winter season, which saw large crowds gathering at the outdoor rink.
The Soo Greyhounds are the talk of the town, as their second-round matchup in the OHL playoffs touches down in the Sault.
Thunder Bay Police Service held a news conference Monday afternoon to discuss the misconduct investigation that led to criminal charges being laid against the city's former police chief.
A pricing agreement has been reached between crab fishers and seafood processors that will allow for Newfoundland and Labrador's annual crab fishery to get started.
Longliners across Newfoundland and Labrador are tied up once again, as a new protest by the province's fish harvesters threatens to derail the crab fishery for a second straight year.
A unique photo exhibit is putting cameras into the hands of survivors of domestic and sexual violence in Newfoundland and Labrador.
The Shopping Trends team is independent of the journalists at CTV News. We may earn a commission when you use our links to shop. Read about us.
