Leonardo DiCaprio criticizes Ottawa over B.C. salmon farms
Salmon farms have long been a point of contention between environmentalists and fish farmers in British Columbia, but a much bigger net is now being cast on the topic.
Pfizer announced Saturday that tweaking its COVID-19 vaccine to better target the Omicron variant is safe and works -- just days before regulators debate whether to offer Americans updated booster shots this fall.
The vaccines currently used in the U.S. still offer strong protection against severe COVID-19 disease and death -- especially if people have gotten a booster dose. But those vaccines target the original coronavirus strain and their effectiveness against any infection dropped markedly when the super-contagious Omicron mutant emerged.
Now with Omicron's even more transmissible relatives spreading widely, the Food and Drug Administration is considering ordering a recipe change for the vaccines made by both Pfizer and rival Moderna in hopes that modified boosters could better protect against another COVID-19 surge expected this fall and winter.
Pfizer and its partner BioNTech studied two different ways of updating their shots -- targeting just Omicron, or a combination booster that adds Omicron protection to the original vaccine. They also tested whether to keep today's standard dosage -- 30 micrograms -- or to double the shots' strength.
In a study of more than 1,200 middle-aged and older adults who'd already had three vaccine doses, Pfizer said both booster approaches spurred a substantial jump in Omicron-fighting antibodies.
"Based on these data, we believe we have two very strong Omicron-adapted candidates," Pfizer CEO Albert Bourla said in a statement.
Pfizer's Omicron-only booster sparked the strongest immune response against that variant.
But many experts say combination shots may be the best approach because they would retain the proven benefits of the original COVID-19 vaccine while adding new protection against Omicron. And Pfizer said a month after people received its combo shot, they had a nine- to 11-fold increase in Omicron-fighting antibodies. That's more than 1.5 times better than another dose of the original vaccine.
And importantly, preliminary lab studies show the tweaked shots also produce antibodies capable of fighting Omicron's genetically distinct relatives named BA.4 and BA.5, although those levels weren't nearly as high.
Moderna recently announced similar results from tests of its combination shot, what scientists call a "bivalent" vaccine.
The studies weren't designed to track how well updated boosters prevented COVID-19 cases. Nor is it clear how long any added protection would last.
But the FDA's scientific advisers will publicly debate the data on Tuesday, as they grapple with whether to recommend a change to the vaccines' recipes -- ahead of similar decisions by other countries.
Salmon farms have long been a point of contention between environmentalists and fish farmers in British Columbia, but a much bigger net is now being cast on the topic.
High winds and turbulence have forced a United Airlines flight from Israel to be diverted from its destination of Newark Airport in New Jersey to Stewart International Airport in New Windsor, N.Y..
The Vancouver Canucks weren’t the only ones who stumbled during Thursday night’s game against the Dallas Stars.
Two men from Senegal froze to death were found in the snow of a wooded area close to the Canadian border, New York state police said.
An historic downtown Toronto bar is closing its doors next week after nearly 200 years in business.
Austin Hunter Turner died in 2017, on a night that his mother has rewound and replayed again and again, trying to make sense of what happened.
Not getting enough sleep may cause you to feel five to 10 years older than you really are, according to two new studies.
Manhattan prosecutors suggested Friday that Donald Trump violated a gag order in his hush-money criminal case this week by assailing the judge's daughter and making a false claim about her on social media.
Niagara Region says it has declared a state of emergency 'out of an abundance of caution' as it prepares for an influx of visitors for next month’s total solar eclipse.
A Toronto restaurant introduced a surprising new rule that reduced the cost of a meal and raised the salaries of staff.
The spring allergy season has started early in many parts of Canada, with high levels of pollen in some cities already. Experts weigh in on which areas have it worse so far this season.
It was a typical Tuesday for Mabel Beharrell, 84, until she got the call that would turn her world upside down. Her teenaged grandson was in trouble and needed her help.
B.C. conservation officers recently seized a nine-foot-long Burmese python from a home in Chilliwack.
A New Brunswicker will go to bed Thursday night much richer than he was Wednesday after collecting on a winning lottery ticket he let sit on his bedroom dresser for nearly a year.
The Ontario government is introducing changes to auto-insurance, but some experts say the move is ill-advised.
Newfoundland’s unique version of the Pine Marten has grown out of its threatened designation.
A Toronto man is out $12,000 after falling victim to a deepfake cryptocurrency scam that appeared to involve Prime Minister Justin Trudeau.
It started small with a little pop tab collection to simply raise some money for charity and help someone — but it didn’t take long for word to get out that 10-year-old Jace Weber from Mildmay, Ont. was quickly building up a large supply of aluminum pop tabs.