Half of Canadians have negative opinion of latest Liberal budget: poll
A new poll suggests the Liberals have not won over voters with their latest budget, though there is broad support for their plan to build millions of homes.
A new analysis of the gout drug colchicine has found no evidence that it lessens the severity of COVID-19 or cuts the risk of death from infection in hospitalized patients.
In turn, the analysis found the drug is associated with a high risk of side effects, namely diarrhea.
The analysis, published in the open access journal RMD Open, looked at available evidence for the use of colchicine, a cheap anti-inflammatory drug normally used to treat gout, to treat COVID-19.
Early observational studies had suggested colchicine may be a useful addition to available COVID-19 treatments, a news release said Monday. The researchers looked through research databases for relevant comparative clinical trial data on the use of the drug for the treatment of COVID-19 published up to July 2021 to clarify its safety and effectiveness.
"Colchicine does not reduce the risk of mortality, need for ventilatory support, intensive care unit admission or length of hospital stay among patients with COVID-19. There is no additional benefit of adding colchicine to supportive care in the management of patients with COVID-19," the researchers concluded.
Six studies found no significant reduction in the risk of death between patients treated with colchicine and those given usual supportive care only. As well, no significant reductions were found in the need for ventilatory support (five studies), admission to intensive care (three studies), length of hospital stay (four studies) or serious side effects (three studies).
The researchers found patients taking colchicine also had a 58 per cent higher rate of side effects and nearly double the risk of diarrhea than those given supportive care.
They said their findings should be interpreted cautiously due to the inclusion of open labelled randomized clinical trials — an open label study is when both the researcher and participant know the drug or treatment being given. As well, they say their analysis was based on a small number of randomized controlled trials in control interventions.
Observational studies, laboratory studies, animal studies and studies with fewer than 10 participants were all excluded. Out of 69 full texts, six randomized controlled trials involving 16,148 patients with varying degrees of severity of COVID-19 were included in the analysis.
In March 2020, during the early months of the COVID-19 pandemic, a team of Canadian researchers, led by director of the Montreal Heart Institute (MHI) Jean-Claude Tardif, announced it had launched a study into the use of colchicine to reduce the risks of pulmonary complications and death related to the coronavirus.
In January 2021, the MHI announced that clinical trials had shown "persuasive results" of the efficacy of colchicine to treat COVID-19, calling it a "major scientific discovery."
However, CTV Montreal reported that many scientists have criticized the research as overstating the benefits of colchicine.
The results were later published in The Lancet Respiratory Medicine. A statement released in May by the MHI said the article concluded that "given the lack of oral therapies available to prevent COVID-19 complications among non-hospitalized patients and the observed benefit of colchicine in patients with a PCR-confirmed diagnosis of COVID-19, this anti-inflammatory drug could be considered as a treatment for those at risk of complications."
A new poll suggests the Liberals have not won over voters with their latest budget, though there is broad support for their plan to build millions of homes.
Appointing a trusted person to help with financial obligations can give you peace of mind. In his personal finance column for CTVNews.ca, Christopher Liew outlines the key benefits of naming a confidant to take over your financial responsibilities, if the need ever arises.
A Toronto couple are speaking out about their “extremely dangerous” experience on board a sinking tour boat in the Dominican Republic last week.
A Winnipeg man said a single date gone wrong led to years of criminal harassment, false arrests, stress and depression.
The federal government has added $36.4 million to a program designed to support people who have been seriously injured or killed by vaccines since the end of 2020.
A photographer who worked for Megan Thee Stallion said in a lawsuit filed Tuesday that he was forced to watch her have sex, was unfairly fired soon after and was abused as her employee.
An Ontario senior’s attempt to get technical help online led him into a spoofing scam where he lost $25,000. Now, he’s sharing his story to warn others.
A Minnesota state senator and former broadcast meteorologist told police that she broke into her stepmother's home because her stepmother refused to give her items of sentimental value from her late father, including his ashes, according to burglary charges filed Tuesday.
When identical twin sisters Kim and Michelle Krezonoski were invited to compete against some of the world’s most elite female runners at last week’s Boston Marathon, they were in disbelief.
When identical twin sisters Kim and Michelle Krezonoski were invited to compete against some of the world’s most elite female runners at last week’s Boston Marathon, they were in disbelief.
The giant stone statues guarding the Lions Gate Bridge have been dressed in custom Vancouver Canucks jerseys as the NHL playoffs get underway.
A local Oilers fan is hoping to see his team cut through the postseason, so he can cut his hair.
A family from Laval, Que. is looking for answers... and their father's body. He died on vacation in Cuba and authorities sent someone else's body back to Canada.
A former educational assistant is calling attention to the rising violence in Alberta's classrooms.
The federal government says its plan to increase taxes on capital gains is aimed at wealthy Canadians to achieve “tax fairness.”
At 6'8" and 350 pounds, there is nothing typical about UBC offensive lineman Giovanni Manu, who was born in Tonga and went to high school in Pitt Meadows.
Kevin the cat has been reunited with his family after enduring a harrowing three-day ordeal while lost at Toronto Pearson International Airport earlier this week.
Molly Knight, a Grade 4 student in Nova Scotia, noticed her school library did not have many books on female athletes, so she started her own book drive in hopes of changing that.