NEW YORK -- Grady Sizemore hit a three-run homer in the sixth inning and the Boston Red Sox finally gave Jon Lester enough run support for his first win of the year, 4-2 over the New York Yankees on Friday night.

Jonny Gomes homered leading off the sixth against CC Sabathia (1-2), and the four-run inning was more than Boston had scored for Lester in his first two starts combined. Despite a 2.51 ERA coming in, Lester (1-2) was at risk of falling to 0-3 for the first time in his career.

The left-hander was lifted with two outs in the seventh after Kelly Johnson singled to pull the Yankees within two runs. Junichi Tazawa relieved with runners at the corners and retired Derek Jeter on a flyout.

Lester allowed Alfonso Soriano's homer starting the second and six hits overall. He improved to 12-5 in 27 starts against New York.

Edward Mujica was perfect in the ninth for his first save with Boston. Red Sox closer Koji Uehara was bothered by shoulder stiffness before the game and was held out as a precaution.

BLUE JAYS 2, ORIOLES 0

BALTIMORE (AP) -- Dustin McGowan allowed five hits over 6 1-3 innings to earn his first win since 2008, and Toronto used two unearned runs to beat Chris Tillman and Baltimore.

Making his second start since September 2011, the oft-injured McGowan (1-1) walked one, hit two batters and struck out two. He had faced the Orioles 13 times previously -- going 0-3 with a 6.99 ERA in 37 1-3 innings.

The right-hander spent time on the disabled list in each of the last six seasons. He had shoulder surgery in 2008 and 2010 and missed the entire 2012 season. In his debut this year, McGowan didn't make it out of the third inning in a loss to the New York Yankees.

Against Baltimore, however, he allowed only one runner past second base for his first win since June 22, 2008.

Brett Cecil got five straight outs and Sergio Santos worked a perfect ninth for his fourth save.

Tillman (1-1) allowed three hits over eight innings, lowering his ERA to 0.84. Two throwing errors by third baseman Jonathan Schoop provided the Blue Jays with a 2-0 lead in the fourth.

RANGERS 1, ASTROS 0, 12 INNINGS

ARLINGTON, Texas (AP) -- Yu Darvish took a perfect game into the sixth inning and Texas finally finished off Houston on Robinson Chirinos' RBI single in the 12th.

Darvish retired his first 15 batters before Matt Dominguez singled softly to centre. The right-hander allowed just the one hit and one walk in eight innings with nine strikeouts.

Darvish came within one out of a perfect game in Houston on April 2 last year, when Marvin Gonzalez grounded a single between the pitcher's legs. He also held the Astros hitless in Houston last Aug. 12 before Carlos Corporan's one-out homer in the eighth.

Texas was 0 for 14 with runners in scoring position and had stranded 15 overall before Chirinos' hit off Brad Peacock (0-1) gave the Rangers their third straight walk-off win.

Jason Frasor (1-0) worked a hitless inning in a combined two-hitter.

WHITE SOX 9, INDIANS 6

CHICAGO (AP) -- Conor Gillaspie had a career-high four RBIs, leading Chris Sale and Chicago over Cleveland.

Sale (3-0) pitched five innings in his first win against Cleveland since May 1, 2012. The left-hander allowed three runs and six hits while throwing 105 pitches.

The White Sox have captured the first two games of their first series of the year against the Indians, who had a 17-2 record against Chicago last season. The teams play again Saturday and Sunday.

Indians starter Carlos Carrasco (0-2) was tagged for five runs and six hits in 4 2-3 innings. Cleveland pitching issued nine walks and walked in two runs.

TWINS 10, ROYALS 1

MINNEAPOLIS (AP) -- Chris Colabello drove in three runs, Kyle Gibson pitched into the seventh inning and Minnesota beat Kansas City to end a nine-game home losing streak that dated to last season.

Josmil Pinto homered for the Twins, who reached double digits in runs for the third time this year.

Minnesota manager Ron Gardenhire was away from the team and also is expected to miss Saturday's game to attend the funeral for Michael Hirschbeck in Ohio. Hirschbeck, the son of umpire John Hirschbeck, died Tuesday at age 27.

Kansas City had won seven straight at Target Field.

After a shaky first inning, Gibson (2-0) settled down. He allowed one run and five hits over 6 1-3 innings to lower his ERA to 1.59.

Royals starter Bruce Chen (0-1) gave up seven hits and six earned runs in 3 2-3 innings.

MARINERS 6, ATHLETICS 4

SEATTLE (AP) -- Felix Hernandez (3-0) took a shutout into the eighth and struck out 11, and Mike Zunino and Brad Miller both homered. Hernandez became the first Seattle pitcher to win three times in the first nine games of a season.

Zunino chased starter Tommy Milone (0-1) with a two-run homer in the sixth. Miller followed two batters later with a solo homer to centre field with the wind blowing in.

Hernandez was charged with two runs and walked none. He has 30 strikeouts and two walks in his three starts.

ANGELS 5, METS 4, 11 INNINGS

ANAHEIM, Calif. (AP) -- Hank Conger was hit by a pitch with the bases loaded in the 11th inning after rookie Jeurys Familia (0-2) intentionally walked the previous two batters, and Los Angeles got home runs from Mike Trout and J.B. Shuck.

Raul Ibanez led off the 11th with a single against Familia (0-2), who was working his third inning of relief. Ibanez advanced on a wild pitch and went to third on a grounder to shortstop by David Freese before Mets manager Terry Collins ordered Familia to walk Howie Kendrick and Shuck.

Michael Kohn (1-0) pitched a perfect inning for the win.

BREWERS 4, PIRATES 2

MILWAUKEE -- Aramis Ramirez hit a two-run homer that backed Wily Peralta, and the Milwaukee Brewers extended their winning streak to seven with a 4-2 victory over the Pittsburgh Pirates on Friday night.

Francisco Liriano befuddled the Brewers with his slider over the first three innings before Ramirez sent a 1-2 fastball over the left-field wall for a 2-0 lead.

At 8-2 on the year, the Brewers are off to their best start since opening with 13 wins in 1987.

Peralta (1-0) allowed four hits in seven innings, but gave up a two-run homer to Neil Walker in the seventh.

Francisco Rodriguez struck out the side in the ninth for his third save.

Liriano (0-2) struck out seven over six innings. He was charged with four runs and four hits.

PHILLIES 6, MARLINS 3

PHILADELPHIA (AP) -- Marlon Byrd drove in two runs and Philadelphia knocked around Jose Fernandez in one of his worst major league starts, beating Miami to snap a four-game skid.

Phillies starter A.J. Burnett left in the fourth inning because of a sore groin, but Philadelphia chased Fernandez (2-1) with three runs in the fifth en route to its first home win of the season.

Fernandez, last season's NL Rookie of the Year, was tagged for eight hits and a career-worst six earned runs in four-plus innings. The right-hander walked four, matching a career high, and struck out six.

Derek Dietrich homered for the Marlins, who lost their fifth straight. Miami has been outscored 32-13 during the slide.

Left-hander Jake Diekman (1-0) got two outs for the win and Jonathan Papelbon pitched a scoreless ninth for his second save in three chances.

BRAVES 7, NATIONALS 6, 10 INNINGS

ATLANTA (AP) -- Jordan Schafer scored from first base on Justin Upton's bloop single to right field with two outs in the 10th inning, giving Atlanta the win.

Chris Johnson singled with two outs off left-hander Jerry Blevins (1-1), and Schafer came in to run. With a 2-2 count, Schafer ran on the pitch and Upton dropped a single in front of Bryce Harper.

Schafer already was rounding third when Harper bobbled the ball. No error was charged.

Luis Avilan (2-1) pitched around two walks, one intentional, in the 10th.

Upton also hit a solo shot in the eighth off Tyler Clippard that tied it at 6. It was his third homer in two games.

DODGERS 6, DIAMONDBACKS 0

PHOENIX (AP) -- Hyun-Jin Ryu pitched seven innings of two-hit ball and Adrian Gonzalez drove in five runs for the Dodgers.

Ryu (2-1) struck out eight and walked one, retiring 18 of his last 19 batters. The only hits off the South Korean left-hander were a pair of singles by Miguel Montero.

Gonzalez hit a two-run homer off Brandon McCarthy (0-2) in the first, doubled in two more in the third and had an RBI single in the eighth. The Dodgers' Hanley Ramirez was 3 for 4 with two doubles, drove in a run and scored three times.

It was the Dodgers' first visit to Chase Field since clinching the NL West title there last September, when they angered the Diamondbacks by celebrating in the ballpark's swimming pool.

CUBS 6, CARDINALS 3, 11 INNINGS

ST. LOUIS (AP) -- Welington Castillo hit a three-run homer off closer Trevor Rosenthal in the 11th inning, leading Chicago to the win.

Rosenthal also struck out with a chance to win the game in the 10th. The Cardinals had runners on first and second with two outs when manager Mike Matheny decided against a pinch hitter. Rosenthal (0-1) took a called third strike in his second career at-bat.

Nate Schierholtz doubled for his fourth straight hit leading off the 11th and advanced on a sacrifice. Starlin Castro was intentionally walked and Ryan Kalish popped out on a bunt attempt before Castillo lined a 1-1 fastball 426 feet to left for his second homer.

Justin Grimm (1-0) got the win and Hector Rondon finished for his first career save.

GIANTS 6, ROCKIES 5

SAN FRANCISCO (AP) -- Madison Bumgarner hit a grand slam and drove in a career-high five runs to overcome a shaky outing on the mound.

Bumgarner hit a sacrifice fly off Jorge De La Rosa (0-2) in the third and one inning later his only the second slam by a Giants pitcher since the team relocated from New York to San Francisco in 1958. Shawn Estes did it against Montreal on May 24, 2000.

Bumgarner (2-0) struck out seven, walked two and allowed four runs and nine hits in six innings. Sergio Romo struck out the side in the ninth for his third save.

PADRES 6, TIGERS 0

SAN DIEGO (AP) -- Andrew Cashner threw his second career one-hitter and struck out a career-high 11, and Chase Headley hit a two-run homer for San Diego.

Cashner took a no-hitter into the sixth inning before Rajai Davis hit a one-out flare single into centre field, just past the glove of outstretched second baseman Jedd Gyorko. Davis stole second and third, and Ian Kinsler walked before Miguel Cabrera hit into a double play.

Cashner (1-1) retired 14 in a row before allowing the single. He walked two.

The Padres hit Rick Porcello (1-1) hard, collecting 10 hits in his 6 1-3 innings. He allowed five runs and struck out five.

RAYS 2, REDS 1

CINCINNATI (AP) -- David Price took a shutout into the ninth and Matt Joyce homered, helping Tampa Bay earn its first victory in Cincinnati.

The teams have a brief and lopsided interleague history. The Reds had won eight of their nine previous games, with Tampa Bay's only win coming at Tropicana Field on June 28, 2011, on Evan Longoria's game-ending homer.

Joyce connected against Johnny Cueto (0-2) as the Rays finally got a victory in their second visit to Great American Ball Park.

Price (2-0) allowed four hits and one walk, losing his shutout when Joey Votto homered to the opposite field with one out in the ninth. Grant Balfour walked the bases loaded in-between getting the final two outs, throwing a called third strike by pinch-hitter Brayan Pena to secure his third save.