TORONTO -- Nelson Cruz hit two of Baltimore's season-high four home runs and Chris Davis and Matt Wieters also connected for the Orioles.

Cruz hit a solo homer off Dustin McGowan in the third and a grand slam off Todd Redmond (0-2) in the fifth, giving him six homers this season and 11 career multihomer games. The slam was his seventh.

Davis hit a solo homer in the first, and Wieters added a solo drive off J.A. Happ in the seventh.

Brett Lawrie hit a three-run homer for Toronto, his second home run in two games. Jose Reyes had a two-run shot and Ryan Goins hit a solo homer, his first this season.

Chris Tillman (3-1) won for the third time in four starts despite allowing seven earned runs, two more than he'd given up in his four previous outings this season combined. Tillman allowed nine hits in 5 2-3 innings, walked two and struck out a season-high seven.

RED SOX 5, YANKEES 1

BOSTON -- Michael Pineda was ejected for using pine tar less than two weeks after appearing to get away with using a foreign substance in another game against Boston, and the Red Sox beat the New York Yankees 5-1 Wednesday night.

The right-hander was thrown out in the second inning when plate umpire Gerry Davis found the substance on the right side of Pineda's neck after Red Sox manager John Farrell asked him to check. Pineda walked from the mound without protest.

Both Pineda and Davis said it was pine tar. Yankees general manager Brian Cashman said Pineda and the organization were "embarrassed."

John Lackey (3-2) allowed one run and seven hits in eight innings with 11 strikeouts and no walks. Koji Uehara struck out three in the ninth in a non-save situation.

Mike Napoli had three hits and Boston scored two runs in the first and two more in the third. The Yankees scored on Alfonso Soriano's sacrifice fly in the sixth.

TWINS 6, RAYS 4, 12 INNINGS

ST. PETERSBURG, Fla. -- Chris Colabello drove in four runs, including two on a 12th-inning single that lifted Minnesota past Tampa Bay.

Colabello's game-winning hit came off Josh Lueke (0-1) after hits by Joe Mauer and Trevor Plouffe.

Casey Fien (1-0) got the win and Glen Perkins pitched the 12th inning for his fourth save.

Colabello drove in Minnesota's first two runs with a fourth-inning home run off Rays starter Jake Odorizzi, his third homer of the season and his second in two nights.

The four RBIs gave the Twins designated hitter a league-leading 26 for the season and tied the franchise record for RBIs in April that Kirby Puckett set in 1994.

Desmond Jennings had three hits, stole two bases and scored twice for the Rays.

MARINERS 5, ASTROS 3

SEATTLE -- Kyle Seager hit a three-run homer with one out in the bottom of the ninth and Seattle rallied to snap an eight-game losing streak.

Seager homered for his second straight at-bat after being mired in a slump for most of the season.

Seager hit a two-run homer in the seventh off Jarred Cosart, then added the winning shot on the first pitch from Josh Fields (0-1) in the ninth. The five RBIs were a career high.

Fernando Rodney (1-1) pitched the ninth for Seattle.

RANGERS 3, ATHLETICS 0

OAKLAND, Calif. -- Martin Perez (4-0) pitched a three-hitter for his second consecutive shutout to extend his scoreless innings streak to 26, helping Texas complete a three-game sweep.

Donnie Murphy homered and Michael Choice scored one run and drove in another for the Rangers, who moved a half-game ahead of Oakland in first place in the AL West with their first sweep of the A's since August 2011.

Sonny Gray (3-1) allowed three runs and five hits in seven innings. He had won six straight regular-season decisions dating to September.

WHITE SOX 6, TIGERS 4

DETROIT -- Marcus Semien's seventh-inning grand slam lifted Chicago over Detroit.

Jose Abreu hit another long home run for the White Sox, but it was Semien's first career slam that turned around the game. Detroit starter Drew Smyly allowed two runs in six innings, but Evan Reed (0-1) gave up two singles and a walk, and Ian Krol allowed the home run to Semien.

Andre Rienzo (1-0) gave up four runs in the fourth inning, but kept the Tigers quiet otherwise in his first start this season. He allowed five hits and two walks in 6 1-3 innings, striking out three.

Matt Lindstrom pitched the ninth for his third save

INDIANS 5, ROYALS 3

CLEVELAND -- Jason Kipnis drove in Nick Swisher with a two-out double in the seventh inning, sending Cleveland past Kansas City.

Kipnis ripped his double off Kelvin Herrera (0-1) into the gap in right-centre, deep enough to easily score Swisher, who reached on a two-out single. The Indians tacked on an insurance run in the eighth on pinch-hitter Lonnie Chisenhall's bloop RBI single.

Bryan Shaw (1-0) finished the seventh and got one out in the eighth. Cody Allen retired two, and John Axford worked the ninth for his AL-leading eighth save.

Salvador Perez and Mike Moustakas hit back-to-back homers in the second for Kansas City.

NATIONAL LEAGUE

DIAMONDBACKS 7, CUBS 5

CHICAGO -- The Chicago Cubs marked Wrigley Field's 100th birthday in dramatic fashion Wednesday, allowing the Arizona Diamondbacks to rally for five runs in the ninth inning and a 7-5 victory.

After an error by shortstop Starlin Castro, Martin Prado hit a two-run single off Pedro Strop (0-2), Miguel Montero had a tying single against James Russell and Aaron Hill followed with a two-run triple off Justin Grimm.

Trevor Cahill (1-3) pitched two scoreless innings for Arizona, which ended a four-game losing streak, and Addison Reed got his fourth save. The game drew 32,323 -- about 9,000 under capacity.

Arizona said after the game that outfielder Mark Trumbo will be sidelined for an unspecified extended period because of a stress fracture in his left foot.

BRAVES 3, MARLINS 1

ATLANTA -- Pinch-hitter Evan Gattis broke an eighth-inning tie with a two-run double off A.J. Ramos as Atlanta took two of three from Miami and won for the ninth time in 12 games overall. The Marlins are 1-8 on the road.

Braves pitchers struck out 16, giving them 41 strikeouts and five walks -- one intentional -- in the three-game series. Miami pitchers struck out 37 and walked nine.

David Carpenter (1-0) got the final out of the eighth, and Craig Kimbrel pitched a perfect ninth for his sixth save. Mike Dunn (1-3) was the loser.

GIANTS 12, ROCKIES 10

DENVER -- Hector Sanchez hit two of San Francisco's six homers, including a grand slam in the 11th off Chad Bettis (0-1).

Michael Morse also hit two homers -- a solo shot in the second and a three-run homer the following inning -- as two Giants hit multiple homers in the same game for the first time since May 25, 2005. Brandon Hicks and Brandon Belt also went deep as the Giants rallied from a 5-1, second-inning deficit.

Jean Machi (4-0) got one out for the win.

METS 3, CARDINALS 2

NEW YORK -- Lucas Duda hit a long home run and New York threw out the potential tying run at the plate in the ninth inning to hold off St. Louis.

Jonathon Niese earned his first win of the season, and shortstop Ruben Tejada cut down Matt Carpenter for the second out of the ninth on a strong relay from centre fielder Kirk Nieuwenhuis.

St. Louis manager Mike Matheny challenged the call, which was upheld following a replay review.

Cardinals right-hander Michael Wacha (2-2) set career highs with 10 strikeouts and five walks in four innings, the shortest of his 14 regular-season starts in the majors.

BREWERS 5, PADRES 2

MILWAUKEE -- Jean Segura hit a three-run homer, and Milwaukee broke out of an offensive slumber at home to support Kyle Lohse.

Segura homered for a 4-1 lead in the second. Khris Davis added a solo shot for the Brewers, who have won five of six and are a big league-best 16-6.

Lohse (4-1) allowed five hits and no walks in seven innings. The Brewers had nine hits at Miller Park, where the team had been averaging just two runs and six hits entering the night.

Francisco Rodriguez pitched a scoreless ninth for his ninth save, his 313th over 12 full big league seasons.

Tyson Ross (2-3) allowed a season-high five earned runs in six innings.

REDS 5, PIRATES 2

PITTSBURGH -- Alfredo Simon pitched into the seventh inning despite erratic control and Jay Bruce drove in a run for a fifth consecutive game to lead Cincinnati.

Simon (3-1) worked 6 2-3 innings and allowed two runs on four hits and five walks while striking out four. He has pitched at least six innings in each of his four starts this season as a replacement for the injured Mat Latos. Simon pitched exclusively in relief the previous two years.

Bruce had two hits and knocked in the final run of the decisive three-run fifth inning against Charlie Morton (0-3) that gave the Reds a 4-2 lead. Billy Hamilton also had two hits for Cincinnati, which has won seven of 10 games since a 3-7 start.

Jonathan Broxton pitched a scoreless ninth inning, despite allowing two hits, for his third save.

INTERLEAGUE

NATIONALS 5, ANGELS 4

WASHINGTON -- Adam LaRoche's tiebreaking RBI single off the first pitch from Fernando Salas capped a four-run rally in the bottom of the ninth inning that kept Washington from getting swept.

Los Angeles led 4-1 entering the ninth, and closer Ernesto Frieri (0-2) went in, seeking his third save.

Instead, he left with his second blown chance, charged with all four runs Washington scored in that inning.

Jose Lobaton led off with his first homer of the season. One out later, Denard Span singled, then Anthony Rendon walked. Frieri then gave up Jayson Werth's two-run double to make it 4-all.

Salas entered, and LaRoche greeted him with a liner to left that scored Werth.

Drew Storen (2-0) got one out in the ninth for the victory.