The death of acclaimed actor Philip Seymour Hoffman drew expressions of sorrow and condolence from a wide range of personalities, fans and high-profile film stars, many of whom worked alongside the 46-year-old at some point during his illustrious movie career.

In a statement, film director Mike Nichols said there were “no words” for the loss. “He was too great and we’re too shattered."

News that Hoffman’s death may have been caused by an apparent drug overdose prompted others, including British comedian Russell Brand, to issue a reminder on the damage substance abuse and addiction can cause.

Here's what some celebrities and fans were saying on Twitter: 


Director Anton Corbjin, who worked with Hoffman in his upcoming film "A Most Wanted Man," issued the following statement:

"He was not only the most gifted actor I ever worked with (and judging by the legacy he leaves behind I am certain I share this with most if not all directors who were fortunate enough to work with him), he had also become an incredibly inspiring and supportive friend. I am so terribly sad as I find it impossible to comprehend what happened today and to collect my thoughts properly. I have to think about Mimi and the children and I wish them much strength coping with the loss of this truly great man as a father and partner."

With files from The Associated Press