Police in southern Ontario are investigating two separate thefts of rare comic books valued at more than $300,000.

Durham regional police say the owner of a comic book business had both his home and workplace broken into at separate times this month.

The first alleged break-in took place on Sept. 18 when police say roughly $54,000 worth of comics went missing from the owner's home in Newcastle, Ont.

Just under a week later, police allege two suspects broke into his warehouse in Pickering, Ont., and stole a box of comics valued at a quarter of a million dollars.

Police say the two male suspects allegedly covered their faces with masks and scarves, and wore gloves during the break-ins.

Anyone with information is encouraged to come forward.